Yang L, Lin Y, Zhang XQ, Liu B, Wang JY. Acute pancreatitis with hypercalcemia caused by primary hyperparathyroidism associated with paraneoplastic syndrome: A case report and review of literature. World J Clin Cases 2021; 9(29): 8906-8914 [PMID: 34734074 DOI: 10.12998/wjcc.v9.i29.8906]
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Oct 16, 2021; 9(29): 8906-8914 Published online Oct 16, 2021. doi: 10.12998/wjcc.v9.i29.8906
Acute pancreatitis with hypercalcemia caused by primary hyperparathyroidism associated with paraneoplastic syndrome: A case report and review of literature
Long Yang, Yue Lin, Xiang-Qun Zhang, Bo Liu, Jun-Yu Wang
Long Yang, Xiang-Qun Zhang, Bo Liu, Jun-Yu Wang, Department of Emergency Medicine Clinical Research Center, Beijing Chao-Yang Hospital, Capital Medical University & Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chaoyang District Gongti South Street 100020, China
Yue Lin, Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, China
Author contributions: Yang L was responsible for material collecting and manuscript drafting; Lin Y, Zhang XQ and Liu B provided important intellectual contents, reviewed the literature; Wang JY contributed to interpreting the clinical materials, designing the structure of manuscript, revising, and modifying the manuscript critically focusing on important intellectual content; All authors gave approval to the final version which would be submitted.
Supported byBeijing Municipal Administration of Hospitals Incubating Program, No. PX2018010.
Informed consent statement: Informed consent was obtained from the patient.
Conflict-of-interest statement: All authors have no conflict of interest related to the manuscript.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Received: June 10, 2021 Peer-review started: June 10, 2021 First decision: June 25, 2021 Revised: July 2, 2021 Accepted: July 30, 2021 Article in press: July 30, 2021 Published online: October 16, 2021 Processing time: 127 Days and 1.1 Hours
Abstract
BACKGROUND
Although acute pancreatitis associated with hyperparathyroidism has occasionally been reported, acute pancreatitis with metabolic encephalopathy caused by hyperparathyroidism combined with paraneoplastic syndrome is an extremely rare entity and poorly described in the literature.
CASE SUMMARY
We present a case of a 56-year-old female with upper abdominal discomfort and intermittent nausea and vomiting for 1 wk, without apparent abdominal pain or bloating, no jaundice and decreased blood pressure at the outset. The patient was ultimately diagnosed with moderately severe acute pancreatitis (according to the revised Atlanta classification of acute pancreatitis) combined with metabolic encephalopathy secondary to hypercalcemia caused by primary hyperparathyroidism associated with paraneoplastic syndrome. After active treatment of acute pancreatitis, massive fluid resuscitation, resection of parathyroid and uterine malignant tumors, neoadjuvant chemotherapy and other treatments, her serum calcium eventually returned to the normal level. The patient was successfully discharged from hospital.
CONCLUSION
This is the first case of acute pancreatitis caused by primary hyperparathyroidism associated with paraneoplastic syndrome.
Core Tip: This is the first case of acute pancreatitis caused by primary hyperparathyroidism associated with paraneoplastic syndrome successfully treated with timely surgery and chemotherapy. This further raises concern for women with refractory hypercalcemia and abnormal vaginal bleeding or abdominal symptoms.
