Published online Sep 26, 2021. doi: 10.12998/wjcc.v9.i27.8135
Peer-review started: April 15, 2021
First decision: June 15, 2021
Revised: June 20, 2021
Accepted: August 12, 2021
Article in press: August 12, 2021
Published online: September 26, 2021
Mucinous gastric carcinoma (MGC) is a rare histological type of gastric car
A 61-year-old man was admitted to our hospital in May 2020 because of a large, tender abdominal mass. Abdominal CT showed diffuse, irregular thickening of the gastric walls, with miliary and punctate calcifications. There were metastases to the perigastric and retroperitoneal lymph nodes and also peritoneal seeding. Histological examination of a specimen obtained by endoscopic biopsy showed poorly differentiated calcified signet-ring cell gastric cancer. The patient was clinically staged with T4N+M1 disease. He was treated with docetaxel, cisplatin, and fluorouracil as first-line therapy, irinotecan combined with S-1 as second-line chemotherapy, and programmed cell death protein 1 as third-line therapy. The patient underwent a total of nine cycles of chemotherapy. Follow-up CT scans every 3 mo showed continually increasing calcifications. As of this writing, the patient has survived almost 1 year.
In this case report, we describe the histopathological and imaging characteristics of a patient with gastric cancer receiving chemotherapy. Multiple punctate calcifications were seen, which gradually increased during chemotherapy. Several possible mechanisms for the calcifications are described, but further research is needed. Future findings may lead to new approaches for the evaluation and treatment of such tumors.
Core Tip: In this report we present a case of gastric mucinous adenocarcinoma with calcification in the gastric wall on computerized tomography evaluation before and after chemotherapy. We explain not only the different theory of the calcification formation and variety, but also the relationship of calcification with prognosis. We hope the results provide new thoughts on tumor evaluation and treatment in the future.