Zhu XW, Zhang CX, Xu TH, Jiang GN, Yao L. Efficacy of roxadustat in treatment of peritoneal dialysis patients with renal anaemia. World J Clin Cases 2021; 9(26): 7682-7692 [PMID: 34621819 DOI: 10.12998/wjcc.v9.i26.7682]
Corresponding Author of This Article
Li Yao, MD, PhD, Director, Professor, Department of Nephrology, The First Affiliated Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang 110001, Liaoning Province, China. liyao_cmu@163.com
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Retrospective Cohort Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Sep 16, 2021; 9(26): 7682-7692 Published online Sep 16, 2021. doi: 10.12998/wjcc.v9.i26.7682
Efficacy of roxadustat in treatment of peritoneal dialysis patients with renal anaemia
Xin-Wang Zhu, Cong-Xiao Zhang, Tian-Hua Xu, Guan-Nan Jiang, Li Yao
Xin-Wang Zhu, Tian-Hua Xu, Guan-Nan Jiang, Li Yao, Department of Nephrology, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Cong-Xiao Zhang, Blood Purification Center, The Fourth People’s Hospital of Shenyang, Shenyang 110031, Liaoning Province, China
Author contributions: Zhu XW designed and performed the research; Zhang CX, Xu TH, and Jiang GN contributed to data analysis; Zhu XW wrote the paper; Yao L revised the paper.
Supported byLiaoning Province Key R&D Guidance Program, No. 2019JH8/10300016; and Liaoning Province Grassroots Health and Family Planning Appropriate Technology Promotion Project, No. LHATP-201801.
Institutional review board statement: The protocol of this study was approved by the Ethics Committee of The First Affiliated Hospital of China Medical University. All procedures performed in studies involving human participants were conducted in accordance with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.
Informed consent statement: Written informed consent was obtained from all patients.
Conflict-of-interest statement: All authors have no conflicts of interest related to the manuscript.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li Yao, MD, PhD, Director, Professor, Department of Nephrology, The First Affiliated Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang 110001, Liaoning Province, China. liyao_cmu@163.com
Received: February 23, 2021 Peer-review started: February 23, 2021 First decision: March 25, 2021 Revised: April 2, 2021 Accepted: July 27, 2021 Article in press: July 27, 2021 Published online: September 16, 2021 Processing time: 198 Days and 22.3 Hours
Abstract
BACKGROUND
There are no studies on the use of roxadustat in patients on regular peritoneal dialysis in China.
AIM
To observe the efficacy and safety of roxadustat in treating renal anaemia in peritoneal dialysis patients.
METHODS
Patients with renal anaemia who were regularly followed at the Peritoneal Dialysis Center of the First Affiliated Hospital of China Medical University from November 1, 2019 to June 30, 2020 were selected. A before-and-after self-control design was performed to retrospectively analyse the treatment effects on anaemia in patients treated with recombinant human erythropoietin (EPO) and roxadustat.
RESULTS
A total of 31 patients with renal anaemia on long-term peritoneal dialysis treated with roxadustat were included. Haemoglobin (Hb) levels were maintained or increased in all patients (100%), and no patients had a decrease in Hb compared with the previous phase. Patients had a mean Hb of 86.2 ± 14.8 g/L with Hb compliance (Hb ≥ 110 g/L) of 16.1% during the EPO phase and a mean Hb of 112.4 ± 18.5 g/L with Hb compliance of 67.7% during the roxadustat phase. No major adverse cardiovascular events occurred in any patient.
CONCLUSION
The application of roxadustat in peritoneal dialysis patients with renal anaemia can effectively improve the Hb compliance rate.
Core Tip: This was a retrospective study to evaluate the efficacy of roxadustat in the treatment of peritoneal dialysis patients with renal anaemia. A before-and-after self-control design was performed on 31 patients treated with recombinant human erythropoietin (EPO) followed by roxadustat. The haemoglobin compliance rate was 16.1% during the EPO phase and 67.7% during the roxadustat phase. Roxadustat can effectively and safely improve the compliance rate in peritoneal dialysis patients with renal anaemia.
