Wang HH, Zhao CC, Wang XL, Cheng ZN, Xie ZY. Menetrier’s disease and differential diagnosis: A case report. World J Clin Cases 2021; 9(23): 6943-6949 [PMID: 34447846 DOI: 10.12998/wjcc.v9.i23.6943]
Corresponding Author of This Article
Zong-Yu Xie, MD, Chief Doctor, Department of Radiology, The First Affiliated Hospital of Bengbu Medical College, No. 287 Changhuai Road, Bengbu 233004, Anhui Province, China. zongyuxie@sina.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Hou-Hong Wang, Department of Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, Anhui Province, China
Can-Can Zhao, Xiao-Lei Wang, Ze-Nong Cheng, Zong-Yu Xie, Department of Radiology, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, Anhui Province, China
Ze-Nong Cheng, Department of Pathology, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, Anhui Province, China
Author contributions: Wang HH and Xie ZY contributed to the conceptualization; Wang HH and Zhao CC contributed to methodology; Xie ZY contributed to the formal analysis and data curation; Wang XL contributed to the writing—original draft preparation; Wang HH and Cheng ZN contributed to supervision; all authors have read and agreed to the published version of the manuscript.
Supported byZhejiang Province Medicine and Health Science and Technology Project, No. 2017178699; Zhejiang Province Medicine and Health Science and Technology Project, No. 2018255136; and Natural Science Foundation of Zhejiang Province, No. Y19H030056.
Informed consent statement: Informed consent was obtained from all subjects involved in the study. Written informed consent has been obtained from the participants to publish this paper.
Conflict-of-interest statement: The authors declare no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zong-Yu Xie, MD, Chief Doctor, Department of Radiology, The First Affiliated Hospital of Bengbu Medical College, No. 287 Changhuai Road, Bengbu 233004, Anhui Province, China. zongyuxie@sina.com
Received: May 7, 2021 Peer-review started: May 7, 2021 First decision: June 6, 2021 Revised: June 6, 2021 Accepted: July 2, 2021 Article in press: July 2, 2021 Published online: August 16, 2021
Abstract
BACKGROUND
Gastric mucosal hypertrophy, also known as Menetrier's disease (MD), is more common in men over 50 years of age, and the cause is unknown. The symptoms of the disease are atypical, mostly accompanied by hypoproteinemia and edema, and sometimes accompanied by symptoms such as epigastric pain, weight loss, and diarrhea. Most experts believe that the site of the disease is mainly located in the fundus of the stomach and the body of the stomach. We found that the site of the disease in this patient involved the antrum of the stomach.
CASE SUMMARY
We introduced the case of a 24-year-old woman who had repeated vomiting for 5 d and was admitted to our hospital. After various examinations such as computed tomography and pathology in our hospital, the final diagnosis of the presented case is MD. The salient feature is that the mucosal folds in the fundus and body of the stomach are huge and present in the shape of gyrus. The greater curvature is more prominent, and there are multiple erosions or ulcers on the folds. The patient did not undergo gastric surgery and did not undergo re-examination. She is drinking Chinese medicine for treatment, and her vomiting and abdominal pain symptoms have improved. This disease is relatively rare in clinical practice, and it is easy to be misdiagnosed as gastric cancer, chronic gastritis and gastric lymphoma, etc.
CONCLUSION
MD can occur in the antrum, it is necessary to raise awareness of the disease and reduce misdiagnosis.
Core Tip: Giant hypertrophy of the gastric mucosa is a proliferative gastric disease that was first discovered by French pathologist Pierre Ménétrier in an autopsy and reported in 1888, and was named Ménétrier disease.
