Published online Jul 26, 2021. doi: 10.12998/wjcc.v9.i21.6067
Peer-review started: March 18, 2021
First decision: April 14, 2021
Revised: April 26, 2021
Accepted: May 7, 2021
Article in press: May 7, 2021
Published online: July 26, 2021
Direct metagenomic next-generation sequencing (mNGS) of clinical samples is an effective method for the molecular diagnosis of infection. However, its role in the diagnosis of patients with acute respiratory distress syndrome (ARDS) of an unknown infectious etiology remains unclear.
A 33-year-old man was admitted to our center for a cough and febrile sensation. Shortly after admission, the patient was diagnosed with ARDS and treated in the intensive care unit. Subsequently, chest computed tomography features suggested an infection. mNGS was performed and the results were indicative of an infection caused by adenovirus type 7. The patient recovered after receiving appropriate treatment.
mNGS is a promising tool for the diagnosis of ARDS caused by infectious agents. However, further studies are required to develop strategies for incorporating mNGS into the current diagnostic process for the disease.
Core Tip: Direct metagenomic next-generation sequencing (mNGS), is useful for infection diagnosis, and has potential for the diagnosis of acute respiratory distress syndrome (ARDS) of unknown infectious etiology. This case report describes the successful use of mNGS for the diagnosis of a patient with ARDS. At his first presentation, the patient was suspected of having an infection based on the results of chest computed tomography. mNGS indicated an infection by adenovirus type 7. The patient recovered with the appropriate treatment. This case highlights the usefulness of mNGS for the diagnosis of ARDS caused by infectious agents.