Zhou F, Xia J, Yuan HX, Sun Y, Zhang Y. Liver injury in COVID-19: Known and unknown. World J Clin Cases 2021; 9(19): 4980-4989 [PMID: 34307548 DOI: 10.12998/wjcc.v9.i19.4980]
Corresponding Author of This Article
Ying Zhang, MD, PhD, Doctor, Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, No. 169 Donghu Road, Wuchang District, Wuhan 430071, Hubei Province, China. ying_zhang@whu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Feng Zhou, Jian Xia, Hai-Xia Yuan, Ying Sun, Department of Endocrinology, Puren Hospital of Wuhan University of Science and Technology, Wuhan 430080, Hubei Province, China
Ying Zhang, Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei Province, China
Author contributions: Zhou F and Xia J contributed to literature search; Zhou F and Yuan HX were in charge of manuscript drafting; Yuan HX and Sun Y contributed to data collection; Zhang Y conceived and designed the study and made substantial revisions to the manuscript.
Supported byZhongnan Hospital of Wuhan University Science, Technology and Innovation Seed Fund, No. znpy2019063.
Conflict-of-interest statement: All authors declare no conflict of interest related to this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ying Zhang, MD, PhD, Doctor, Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, No. 169 Donghu Road, Wuchang District, Wuhan 430071, Hubei Province, China. ying_zhang@whu.edu.cn
Received: January 27, 2021 Peer-review started: January 27, 2021 First decision: February 25, 2021 Revised: March 13, 2021 Accepted: May 8, 2021 Article in press: May 8, 2021 Published online: July 6, 2021 Processing time: 147 Days and 15.2 Hours
Abstract
Since the first report of the coronavirus disease 2019 (COVID-19) in December 2019 in Wuhan, China, the outbreak of the disease is currently continuously evolving. Previous studies have shown varying degrees of liver damage in patients with COVID-19. However, the exact causes of liver injury and the relationship between COVID-19 and liver injury is unclear. This article describes liver injury induced by COVID-19, analyzes its causes, and discusses the treatment and prognosis of liver damage in patients with COVID-19.
Core Tip: This review describes the causes of liver injury in patients with coronavirus disease 2019 (COVID-19), including inflammatory storms, hypoxia, drug factors, and viral damage to liver cells, and discusses the treatment of liver injury with COVID-19, which we believe to be beneficial to manage COVID-19 patients with liver injury well and improve their prognosis.
