Minireviews
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 6, 2021; 9(19): 4980-4989
Published online Jul 6, 2021. doi: 10.12998/wjcc.v9.i19.4980
Liver injury in COVID-19: Known and unknown
Feng Zhou, Jian Xia, Hai-Xia Yuan, Ying Sun, Ying Zhang
Feng Zhou, Jian Xia, Hai-Xia Yuan, Ying Sun, Department of Endocrinology, Puren Hospital of Wuhan University of Science and Technology, Wuhan 430080, Hubei Province, China
Ying Zhang, Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei Province, China
Author contributions: Zhou F and Xia J contributed to literature search; Zhou F and Yuan HX were in charge of manuscript drafting; Yuan HX and Sun Y contributed to data collection; Zhang Y conceived and designed the study and made substantial revisions to the manuscript.
Supported by Zhongnan Hospital of Wuhan University Science, Technology and Innovation Seed Fund, No. znpy2019063.
Conflict-of-interest statement: All authors declare no conflict of interest related to this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ying Zhang, MD, PhD, Doctor, Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, No. 169 Donghu Road, Wuchang District, Wuhan 430071, Hubei Province, China. ying_zhang@whu.edu.cn
Received: January 27, 2021
Peer-review started: January 27, 2021
First decision: February 25, 2021
Revised: March 13, 2021
Accepted: May 8, 2021
Article in press: May 8, 2021
Published online: July 6, 2021
Processing time: 147 Days and 15.2 Hours
Abstract

Since the first report of the coronavirus disease 2019 (COVID-19) in December 2019 in Wuhan, China, the outbreak of the disease is currently continuously evolving. Previous studies have shown varying degrees of liver damage in patients with COVID-19. However, the exact causes of liver injury and the relationship between COVID-19 and liver injury is unclear. This article describes liver injury induced by COVID-19, analyzes its causes, and discusses the treatment and prognosis of liver damage in patients with COVID-19.

Keywords: SARS-CoV-2; COVID-19; Liver injury; Prognosis; Treatment

Core Tip: This review describes the causes of liver injury in patients with coronavirus disease 2019 (COVID-19), including inflammatory storms, hypoxia, drug factors, and viral damage to liver cells, and discusses the treatment of liver injury with COVID-19, which we believe to be beneficial to manage COVID-19 patients with liver injury well and improve their prognosis.