Umwali Y, Yue CB, Gabriel ANA, Zhang Y, Zhang X. Roles of exosomes in diagnosis and treatment of colorectal cancer. World J Clin Cases 2021; 9(18): 4467-4479 [PMID: 34222415 DOI: 10.12998/wjcc.v9.i18.4467]
Corresponding Author of This Article
Xin Zhang, FRS, MD, PhD, Academic Fellow, Associate Professor, Department of Clinical Laboratory, Qilu Hospital, Shandong University, No. 107 Wenhua West Road, Jinan 250012, Shandong Province, China. xinzhang@sdu.edu.cn
Research Domain of This Article
Oncology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Yvette Umwali, Cong-Bo Yue, Yi Zhang, Xin Zhang, Department of Clinical Laboratory, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong Province, China
Abakundana Nsenga Ariston Gabriel, Department of Clinical Laboratory, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong Province, China
Author contributions: Umwali Y drafted the manuscript; Yue CB and Gabriel ANA collected the information; Zhang X and Zhang Y designed and revised the manuscript; Zhang X and Zhang Y are co-corresponding authors; all authors read and approved the final manuscript.
Supported byNational Natural Science Foundation of China, No. 81972005; Natural Science Foundation of Shandong Province, No. ZR2020MH238; and Shandong Medical and Health Technology Development Project, No. 2018WSB20002.
Conflict-of-interest statement: The authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xin Zhang, FRS, MD, PhD, Academic Fellow, Associate Professor, Department of Clinical Laboratory, Qilu Hospital, Shandong University, No. 107 Wenhua West Road, Jinan 250012, Shandong Province, China. xinzhang@sdu.edu.cn
Received: January 22, 2021 Peer-review started: January 22, 2021 First decision: February 28, 2021 Revised: March 15, 2021 Accepted: May 6, 2021 Article in press: May 6, 2021 Published online: June 26, 2021
Abstract
Exosomes are extracellular vesicles that mediate intercellular communication. They contain different molecules, such as DNA, RNA, lipid, and protein, playing essential roles in the pathogenesis of colorectal cancer (CRC). Exosomes derived from CRC are implicated in tumorigenesis, chemotherapy resistance, and metastasis. Besides, they can enhance CRC progression by increasing tumor cell proliferation, reducing apoptosis mechanistically through altering particular essential regulatory genes, or controlling several signaling pathways. Therefore, exosomes derived from CRC are essential biomarkers and can be used in the diagnosis. Indeed, it is crucial to understand the role of exosomes in CRC, which is necessary to develop diagnostic and therapeutic strategies for early detection and treatment. In the present review, we discuss the roles of exosomes in the diagnosis and treatment of CRC.
Core Tip: Exosomes are extracellular vesicles that mediate intercellular communication. They contain molecules such as RNAs, DNA, lipids, and proteins, whose role is essential in the pathogenesis of colorectal cancer (CRC). Exosomes derived from CRC are implicated in tumorigenesis, chemotherapy resistance, and metastasis. Besides, they can enhance CRC progression by increasing tumor cell proliferation, reducing apoptosis mechanistically through upregulation or downregulation of particular essential regulatory genes, or controlling several signaling pathways. Therefore, exosomes derived from CRCs are essential biomarkers and can be used in the diagnosis.
