Wu GJ, Li BB, Zhu RL, Yang CJ, Chen WY. Rosai-Dorfman disease with lung involvement in a 10-year-old patient: A case report. World J Clin Cases 2021; 9(17): 4285-4293 [PMID: 34141792 DOI: 10.12998/wjcc.v9.i17.4285]
Corresponding Author of This Article
Wen-Yong Chen, MS, Doctor, Department of Otolaryngology, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, No. 111 Dade Road, Yuexiu District, Guangzhou 510120, Guangdong Province, China. gzdoctorcwy@126.com
Research Domain of This Article
Otorhinolaryngology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Guo-Jing Wu, Wen-Yong Chen, The Second Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510000, Guangdong Province, China
Guo-Jing Wu, Bo-Bo Li, Ren-Liang Zhu, Chao-Jie Yang, Wen-Yong Chen, Department of Otolaryngology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, Guangdong Province, China
Author contributions: Li BB, Zhu RL, and Chen WY discovered this case; Wu GJ and Chen WY contributed to manuscript drafting; Li BB and Yang CJ collected the data; Wu GJ, Zhu RL, and Chen WY followed the patient; all authors had read and approved the final manuscript.
Supported byDiscipline Upgrading Program of Guangzhou University of Traditional Chinese Medicine: Clinical and Basic Research on Prevention and Treatment of Otorhinolaryngology with the Combination of Traditional Chinese and Western Medicine, No. A3-0402-20-415-107 (Undetermined).
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors have no funding, financial relationships, or conflicts of interest to disclose.
CARE Checklist (2016) statement: The guidelines of the “CARE Checklist–2016: Information for writing a case report” have been adopted.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wen-Yong Chen, MS, Doctor, Department of Otolaryngology, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, No. 111 Dade Road, Yuexiu District, Guangzhou 510120, Guangdong Province, China. gzdoctorcwy@126.com
Received: January 15, 2021 Peer-review started: January 15, 2021 First decision: February 11, 2021 Revised: February 22, 2021 Accepted: March 29, 2021 Article in press: March 29, 2021 Published online: June 16, 2021 Processing time: 131 Days and 4.8 Hours
Abstract
BACKGROUND
Rosai-Dorfman disease (RDD) is a rare benign proliferative disease whose etiology is not clear and may be related to infection or unexplained immune dysfunction. The authors present a case of RDD with lung involvement in a 10-year-old patient.
CASE SUMMARY
A 10-year-old girl found that her left cervical lymph nodes were enlarged for more than 7 mo, and the largest range was about 6.5 cm × 5.9 cm × 8.1 cm. Cervical magnetic resonance imaging showed multiple masses in the left neck, with low signal intensity on T1-weighted images and high signal intensity on T2-weighted images. A malignant tumor, with a high possibility of lymph node metastasis, was initially considered. At the same time, lung computed tomography showed multiple nodules of different sizes scattered on both sides of the lung, with uniform internal density. Thus, a possible metastatic tumor was considered. Finally, RDD was diagnosed by pathology and immunohistochemistry. According to the antibiogram, clindamycin was administered for 2 wk, and prednisone acetate was administered for 7 wk. Nine months later, the ulcer in the left neck was better than before, but the imaging showed that the lesion was not controlled.
CONCLUSION
The diagnosis of RDD cannot be made by a single tool and its treatment is a long-term exploratory process. Follow-up is necessary.
Core Tip: In this paper we report a 10-year-old girl characterized by enlarged left cervical lymph nodes. Imaging suggested a malignant tumor with pulmonary metastasis, and Rosai-Dorfman disease (RDD) was finally diagnosed by pathological and immunohistochemical methods. This case suggests that attention should be paid to RDD in the differential diagnosis of cervical masses. Second, the diagnosis of RDD should not rely solely on imaging examination, and different diagnostic methods should be used. Moreover, although rare, there is a situation that RDD involves the lungs. Finally, the treatment of RDD needs to be constantly explored and the treatment plan should be adjusted according to the follow-up results.
