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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Parotid mammary analogue secretory carcinoma: A case report and review of literature
Feng-He Min, Jia Li, Bo-Qiang Tao, Hui-Min Liu, Zhi-Jing Yang, Lu Chang, Yu-Yang Li, Ying-Kun Liu, Yi-Wen Qin, Wei-Wei Liu
Feng-He Min, Jia Li, Bo-Qiang Tao, Hui-Min Liu, Zhi-Jing Yang, Lu Chang, Ying-Kun Liu, Wei-Wei Liu, Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin University, Changchun 130021, Jilin Province, China
Feng-He Min, Bo-Qiang Tao, Hui-Min Liu, Zhi-Jing Yang, Lu Chang, Yu-Yang Li, Ying-Kun Liu, Wei-Wei Liu, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Changchun 130021, Jilin Province, China
Yu-Yang Li, Department of Oral Implant, Hospital of Stomatology, Jilin University, Changchun 130021, Jilin Province, China
Yi-Wen Qin, Department of Stomatology, Chongqing Medical University, Chongqing 400016, China
Author contributions: Min FH and Li J contributed equally to this work; Tao BQ, Liu HM, Yang ZJ, Chang L, Li YY, Liu YK, and Qin YW collected and analyzed the data; Min FH and Li J prepared the manuscript; Liu WW, Min FH, and Li J revised and drafted this manuscript; Liu WW provided the funding support in the study; All authors read and approved the final manuscript.
Supported by International Science and Technology Cooperation Project of Jilin Province Science and Technology Department, China, No. 20200801077GH; Science and Technology Project of Jilin Provincial Department of Finance, China, No. JCSZ2019378-8; Jilin Provincial Development and Reform Commission Project, China, No. 2019C051-5.
Informed consent statement: Informed written consent was obtained from the patient to publish this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
http://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Wei-Wei Liu, PhD, Chief Physician, Professor, Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin University, No. 1500 Qinghua Road, Changchun 130021, Jilin Province, China.
liuweiw@jlu.edu.cn
Received: January 18, 2021
Peer-review started: January 18, 2021
First decision: February 11, 2021
Revised: February 17, 2021
Accepted: March 13, 2021
Article in press: March 13, 2021
Published online: June 6, 2021
Processing time: 115 Days and 18 Hours
BACKGROUND
Mammary analogue secretory carcinoma (MASC) is a rare low-grade malignant salivary gland tumor. The morphological and immunohistochemical features of MASC closely resemble those of breast secretory carcinoma. The key characteristics of the lesion are a lack of pain and slow growth. There is no obvious specificity in the clinical manifestations and imaging features. The diagnosis of the disease mainly depends on the detection of the MASC-specific ETV6-NTRK3 fusion gene.
CASE SUMMARY
This report describes a rare case of a 32-year-old male patient who presented with a gradually growing lesion that was initially diagnosed as breast-like secretory carcinoma of the right parotid gland. Imaging and histological investigations were used to overcome the diagnostic difficulties. The lesion was managed with right parotidectomy, facial nerve preservation, biological patch implantation to restore the resulting defect, and postoperative radiotherapy. On postoperative follow-up, the patient reported a mild facial deformity with no complications, signs of facial paralysis, or Frey’s syndrome.
CONCLUSION
The imaging and histological diagnostic challenges for MASC are discussed.
Core Tip: Mammary analogue secretory carcinoma is a rare low-grade malignant salivary gland tumor. The morphological and immunohistochemical features of mammary analogue secretory carcinoma closely resemble those of breast secretory carcinoma. The key characteristics of the lesion are a lack of pain and slow growth. There is no obvious specificity in the clinical manifestations and imaging features. The diagnosis of this disease is particularly difficult. This report describes a rare case of a 32-year-old male patient who presented with a gradually growing lesion that was initially diagnosed as breast-like secretory carcinoma of the right parotid gland. Imaging and histological investigations were used to overcome the diagnostic difficulties.
