Jiang LL, Li H, Liu L. Xenogeneic stem cell transplantation: Research progress and clinical prospects. World J Clin Cases 2021; 9(16): 3826-3837 [PMID: 34141739 DOI: 10.12998/wjcc.v9.i16.3826]
Corresponding Author of This Article
Lei Liu, MD, PhD, Professor, State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, No. 14 Section 3 Renmin Nan Road, Chengdu 610041, Sichuan Province, China. drliulei@163.com
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jun 6, 2021; 9(16): 3826-3837 Published online Jun 6, 2021. doi: 10.12998/wjcc.v9.i16.3826
Xenogeneic stem cell transplantation: Research progress and clinical prospects
Lin-Li Jiang, Hui Li, Lei Liu
Lin-Li Jiang, Hui Li, Lei Liu, State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Jiang LL contributed to the literature review and drafting and writing of this paper as the first author; Li H contributed to the literature review and drafting of this paper as the second author; Liu L contributed to the revision and editing of the manuscript, and gave approval to the final version as the corresponding author.
Supported byNational Natural Science Foundation of China, No. 81670951.
Conflict-of-interest statement: There are no potential conflicts of interest to report.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lei Liu, MD, PhD, Professor, State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, No. 14 Section 3 Renmin Nan Road, Chengdu 610041, Sichuan Province, China. drliulei@163.com
Received: January 27, 2021 Peer-review started: January 27, 2021 First decision: March 8, 2021 Revised: March 15, 2021 Accepted: March 23, 2021 Article in press: March 23, 2021 Published online: June 6, 2021
Abstract
Organ transplantation is the ultimate treatment for end-stage diseases such as heart and liver failure. However, the severe shortage of donor organs has limited the organ transplantation progress. Xenogeneic stem cell transplantation provides a new strategy to solve this problem. Researchers have shown that xenogeneic stem cell transplantation has significant therapeutic effects and broad application prospects in treating liver failure, myocardial infarction, advanced type 1 diabetes mellitus, myelosuppression, and other end-stage diseases by replacing the dysfunctional cells directly or improving the endogenous regenerative milieu. In this review, the sources, problems and solutions, and potential clinical applications of xenogeneic stem cell transplantation will be discussed.
Core Tip: The severe shortage of donor organs generates long waiting lists for patients with end-stage diseases anticipating organ transplantation and ultimately leads to the deaths for those who are not fortunate to receive an organ. Xenogeneic stem cell transplantation provides a new strategy to solve this problem. In this review, we summarize possible problems and solutions and the clinical prospects of xenogeneic stem cell transplantation.
