Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 26, 2021; 9(15): 3765-3772
Published online May 26, 2021. doi: 10.12998/wjcc.v9.i15.3765
De novo multiple primary carcinomas in a patient after liver transplantation: A case report
Wei Rao, Fu-Guo Liu, Yue-Ping Jiang, Man Xie
Wei Rao, Division of Hepatology, Liver Disease Center, The Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, China
Wei Rao, Department of Organ Transplantation, The Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, China
Fu-Guo Liu, Yue-Ping Jiang, Man Xie, Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, China
Author contributions: Rao W contributed to data curation and analysis, and original manuscript drafting; Liu FG and Jiang YP contributed to manuscript writing, review, and editing; Xie M contributed to funding acquisition, conceptualization, supervision, and manuscript writing, review, and editing.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors of this manuscript have no conflicts of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Man Xie, MD, PhD, Assistant Professor, Associate Chief Physician, Department of Gastroenterology, The Affiliated Hospital of Qingdao University, No. 59 Hai'er Road, Laoshan District, Qingdao 266000, Shandong Province, China. xieman1123@126.com
Received: January 9, 2021
Peer-review started: January 9, 2021
First decision: February 12, 2021
Revised: February 15, 2021
Accepted: March 8, 2021
Article in press: March 8, 2021
Published online: May 26, 2021
Processing time: 121 Days and 23.7 Hours
Abstract
BACKGROUND

Liver transplantation (LT) is the most effective treatment strategy for advanced liver diseases. With the increasing survival rate and prolonged survival time, the postoperative long-term complications of LT recipients are becoming an important concern. Among them, the newly developed cancer after LT is the second complication and cause of LT-related death after cardiovascular disease. At present, few papers have reported multiple primary carcinomas (MPCs) after LT. Herein, we retrospectively analyzed an MPC case with gastric cancer and lung cancer after LT.

CASE SUMMARY

Herein, we retrospectively analyzed an MPC case with de novo gastric cancer and lung cancer after LT with no obvious complaints. Forty-one months after LT, the patient underwent radical distal gastrectomy (Billroth II) for intramucosal signet ring cell carcinoma, and then thoracoscopic wedge resection of the right lower lobe of the right lung and localized lymph node dissection 2 mo later. Therefore, paying attention to follow-up in LT recipients with early detection and intervention of de novo MPCs is the key to improving the survival rate and quality of life of LT recipients.

CONCLUSION

De novo MPCs after LT are rare, and the prognosis is poorer. However, early detection and related intervention can significantly improve the prognosis of patients. Therefore, we recommend that liver transplant recipients should be followed and screened for newly developed malignant tumors to improve the survival rate and quality of life.

Keywords: Liver transplantation; de novo tumors; Multiple primary carcinomas; Screening; Case report

Core Tip: Few papers have reported de novo multiple primary carcinomas (MPCs) after liver transplantation (LT) yet. Herein, we retrospectively analyzed an MPC case with gastric cancer and lung cancer after LT. Forty-one months after LT, the patient underwent radical distal gastrectomy for a de novo intramucosal signet ring cell carcinoma in the stomach. Two months later, the patient underwent thoracoscopic wedge resection of the right lower lobe of the right lung for the de novo lung cancer. The patient has survived till now with stable function of the graft. Early diagnosis and early treatment of de novo MPCs are the keys to improving the survival rate and quality of life of LT recipients with de novo MPCs.