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World J Clin Cases. Apr 26, 2021; 9(12): 2703-2710
Published online Apr 26, 2021. doi: 10.12998/wjcc.v9.i12.2703
Mediastinal lymphadenopathy in COVID-19: A review of literature
Pahnwat Tonya Taweesedt, Salim Surani
Pahnwat Tonya Taweesedt, Department of Medicine, Corpus Christi Medical Center, Corpus Christi, TX 78404, United States
Salim Surani, Department of Pulmonary Critical Care and Sleep Medicine, Texas A and M Health Science Center, Bryan, TX 77807, United States
Author contributions: Taweesedt PT and Surani S have contributed to case management, idea, literature search, writing and revision of manuscript.
Conflict-of-interest statement: There is no conflict of interest associated with any of the senior author or other coauthors contributed their efforts in this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Salim Surani, FACC, FACP, FCCP, MD, Professor, Department of Pulmonary Critical Care and Sleep Medicine, Texas A and M Health Science Center, 8441 Riverside Pkwy, Bryan, TX 77807, United States. srsurani@gmail.com
Received: November 14, 2020
Peer-review started: November 14, 2020
First decision: December 28, 2020
Revised: January 1, 2021
Accepted: March 11, 2021
Article in press: March 11, 2021
Published online: April 26, 2021
Processing time: 151 Days and 23.8 Hours
Abstract

A novel coronavirus disease 2019 (COVID-19) is a progressive viral disease that affected people around the world with widespread morbidity and mortality. Patients with COVID-19 infection typically had pulmonary manifestation but can also present with gastrointestinal, cardiac, or neurological system dysfunction. Chest imaging in patients with COVID-19 commonly show bilateral lung involvement with bilateral ground-glass opacity and consolidation. Mediastinal lymphadenopathy can be found due to infectious or non-infectious etiologies. It is commonly found to be associated with malignant diseases, sarcoidosis, and heart failure. Mediastinal lymph node enlargement is not a typical computer tomography of the chest finding of patients with COVID-19 infection. We summarized the literature which suggested or investigated the mediastinal lymph node enlargement in patients with COVID-19 infection. Further studies are needed to better characterize the importance of mediastinal lymphadenopathy in patients with COVID-19 infection.

Keywords: Mediastinal lymphadenopathy; Lymph node enlargement; COVID-19; Novel corona virus; Long term coronavirus disease-sequala; Coronavirus disease complications

Core Tip: This reviewed summarized the articles with mediastinal lymphadenopathy evaluation in the patients with a novel coronavirus disease 2019. The content will help understand more regarding current prevalence of mediastinal lymphadenopathy in this population.