Jiang L, Qin B, Luo XL, Cao H, Deng TM, Yang MM, Meng T, Yang HQ. Three-year follow-up of Coats disease treated with conbercept and 532-nm laser photocoagulation. World J Clin Cases 2020; 8(24): 6243-6251 [PMID: 33392305 DOI: 10.12998/wjcc.v8.i24.6243]
Corresponding Author of This Article
Bo Qin, MD, Doctor, Shenzhen Aier Eye Hospital Affiliated to Jinan University, No. 1017 Dongmen North Road, Luohu District, Shenzhen 518020, Guangdong Province, China. jiang.li@szhospital.com
Research Domain of This Article
Ophthalmology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Dec 26, 2020; 8(24): 6243-6251 Published online Dec 26, 2020. doi: 10.12998/wjcc.v8.i24.6243
Three-year follow-up of Coats disease treated with conbercept and 532-nm laser photocoagulation
Li Jiang, Bo Qin, Xiao-Ling Luo, He Cao, Ting-Ming Deng, Ming-Ming Yang, Ting Meng, Hui-Qin Yang
Li Jiang, Xiao-Ling Luo, He Cao, Ting-Ming Deng, Ming-Ming Yang, Ting Meng, Hui-Qin Yang, Department of Ophthalmology, Shenzhen People’s Hospital, Second Clinical Medical College of Jinan University, Shenzhen 518020, Guangdong Province, China
Bo Qin, Department of Ophthalmology, Shenzhen Aier Eye Hospital Affiliated to Jinan University, Shenzhen 518032, Guangdong Province, China
Author contributions: Jiang L was responsible for the conception of the article, case analysis, statistics and article writing and was the main contributor to the writing of the manuscript; Qin B and Luo XL were responsible for the guidance and revision of the article; Cao H was responsible for assisting with the query of literature and analysis of statistical results; Deng TM collected and reviewed follow-up records of major cases; Yang MM, Meng T and Yang HQ were responsible for the collection of case data and assisting with document search; All authors have read and approved the manuscript.
Supported bythe Shenzhen Municipal Health and Family Planning System Research Project, No. SZFZ2017085.
Institutional review board statement: The study was approved by the ethics committee of Shenzhen People’s Hospital (No. LL-KY-2020238).
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: Not applicable.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bo Qin, MD, Doctor, Shenzhen Aier Eye Hospital Affiliated to Jinan University, No. 1017 Dongmen North Road, Luohu District, Shenzhen 518020, Guangdong Province, China. jiang.li@szhospital.com
Received: August 4, 2020 Peer-review started: August 4, 2020 First decision: August 21, 2020 Revised: September 22, 2020 Accepted: November 2, 2020 Article in press: November 2, 2020 Published online: December 26, 2020 Processing time: 137 Days and 3.8 Hours
Abstract
BACKGROUND
Coats disease is an idiopathic exudative outer retinopathy caused by abnormal retinal vascular development.
AIM
To evaluate the long-term outcomes of intravitreal conbercept injection with laser photocoagulation as a treatment for Coats disease in adults.
METHODS
This retrospective case series study included patients diagnosed with Coats disease and treated with intravitreal conbercept injection and 532-nm laser photocoagulation at the Ophthalmology Department of Shenzhen People’s Hospital between January 2016 and January 2017. Best-corrected visual acuity (BCVA) measurements, noncontact tonometry, ophthalmoscopy, fundus photography, fundus fluorescein angiography and optical coherence tomography were performed before treatment and at 1 wk, 1 mo, 3 mo, 6 mo, 9 mo, 12 mo, 24 mo and 36 mo after therapy. Best-corrected visual acuity was measured using the early treatment of diabetic retinopathy study chart.
RESULTS
The study included eight eyes of 8 patients (7 men) aged 36.10 ± 6.65 years. The average BCVA of the affected eye before treatment was 51.17 ± 15.15 letters (range, 28–70 letters), and the average central macular thickness was 303.30 ± 107.87 µm (range, 221–673 µm). Four eyes were injected once, three were injected twice, and one was injected three times. Average follow-up duration was 37.33 ± 2.26 mo. Average BCVA of the affected eye was 51.17 ± 15.15 letters before treatment and was increased by 13.50 ± 3.20, 16.25 ± 7.73, 18.25 ± 8.96, 18.03 ± 5.27, 18.63 ± 3.35, 19.75 ± 6.96, 18.05 ± 5.36 and 17.88 ± 3.45 letters at 1 wk, 1 mo, 3 mo, 6 mo, 9 mo, 12 mo, 24 mo and 36 mo after treatment, respectively (P < 0.01). The patients showed varying degrees of subretinal fluid resorption after treatment. None of the patients had serious complications such as increased intraocular pressure, development/progression of cataracts, endophthalmitis or retinal detachment.
CONCLUSION
Intravitreal injection of conbercept combined with 532-nm laser photocoagulation may be a feasible treatment for Coats disease in adult patients.
Core Tip: Coats disease is an idiopathic exudative outer retinopathy caused by abnormal retinal vascular development. Intravitreal injection of conbercept combined with 532-nm laser photocoagulation may be a feasible treatment for Coats disease in adult patients.
