Ge X, Luan X. Uncontrolled central hyperthermia by standard dose of bromocriptine: A case report. World J Clin Cases 2020; 8(23): 6158-6163 [PMID: 33344618 DOI: 10.12998/wjcc.v8.i23.6158]
Corresponding Author of This Article
Xin Ge, MD, PhD, Assistant Professor, Director, Department of intensive care unit, Wuxi 9th Affiliated Hospital of Soochow University, Hand Institution of Wuxi City, No. 999 Liangxi Road, WuXi 214000, Jiangsu Province, China. sirgexin@163.com
Research Domain of This Article
Critical Care Medicine
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Dec 6, 2020; 8(23): 6158-6163 Published online Dec 6, 2020. doi: 10.12998/wjcc.v8.i23.6158
Uncontrolled central hyperthermia by standard dose of bromocriptine: A case report
Xin Ge, Xue Luan
Xin Ge, Department of Intensive Care Unit, Wuxi 9th Affiliated Hospital of Soochow University, Hand Institution of Wuxi City, Wuxi 214000, Jiangsu Province, China
Xin Ge, Traumatic Center, Wuxi 9th Affiliated Hospital of Soochow University, Hand Institution of Wuxi City, Wuxi 214000, Jiangsu Province, China
Xue Luan, Department of Neurosurgery, Central Hospital of Jinzhou, Jinzhou 121000, Liaoning Province, China
Author contributions: Ge X contributed to the concept, drafting, reporting, and revising of the case; Luan X acquired clinical data and revised the manuscript. All authors have read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xin Ge, MD, PhD, Assistant Professor, Director, Department of intensive care unit, Wuxi 9th Affiliated Hospital of Soochow University, Hand Institution of Wuxi City, No. 999 Liangxi Road, WuXi 214000, Jiangsu Province, China. sirgexin@163.com
Received: July 11, 2020 Peer-review started: July 11, 2020 First decision: September 24, 2020 Revised: September 30, 2020 Accepted: October 20, 2020 Article in press: October 20, 2020 Published online: December 6, 2020 Processing time: 146 Days and 2.6 Hours
Abstract
BACKGROUND
Some patients present to the intensive care unit due to noninfectious pathologies resulting in fever, especially acute neurological injuries, including brain trauma and intracranial haemorrhage. The cause has been identified to be central hyperthermia characterized by a high core temperature and a poor response to antipyretics and antibiotics. However, no proper guidelines on how to treat central hyperthermia have been developed for clinical practice.
CASE SUMMARY
A 63-year-old woman was transferred to our hospital due to injury after a traffic accident. Eight hours after admission, her pupils enlarged bilaterally from 2.5 mm to 4.0 mm. She developed severe coma and underwent decompressive craniectomy. She was diagnosed with central hyperthermia after surgery and was prescribed bromocriptine. The standard dose of bromocriptine could not control her hyperpyrexia, and we prescribed 30 mg a day to control her temperature.
CONCLUSION
Bromocriptine may be effective in controlling central hyperthermia and have a dosage effect.
Core Tip: Central hyperthermia is characterized by a high core temperature and a poor response to antipyretics and antibiotics. No guidelines on how to treat central hyperthermia have been developed for clinical practice, but bromocriptine has been reported to control the condition effectively. A unique female patient who had central hyperthermia that could not be controlled by a standard dose of bromocriptine was treated in our department. We prescribed 30 mg bromocriptine per day to control her hyperpyrexia.
