Chen ZZ, Huang W, Wei ZQ. Small-cell neuroendocrine carcinoma of the rectum — a rare tumor type with poor prognosis: A case report and review of literature. World J Clin Cases 2020; 8(23): 6095-6102 [PMID: 33344610 DOI: 10.12998/wjcc.v8.i23.6095]
Corresponding Author of This Article
Zheng-Qiang Wei, MD, Doctor, Lecturer, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuanjiagang, Chongqing 400000, China. 384535713@qq.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Dec 6, 2020; 8(23): 6095-6102 Published online Dec 6, 2020. doi: 10.12998/wjcc.v8.i23.6095
Small-cell neuroendocrine carcinoma of the rectum — a rare tumor type with poor prognosis: A case report and review of literature
Zhen-Zhou Chen, Wang Huang, Zheng-Qiang Wei
Zhen-Zhou Chen, Wang Huang, Zheng-Qiang Wei, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400000, China
Author contributions: Chen ZZ performed the case report and wrote the manuscript; Huang W edited the manuscript; Wei ZQ supervised the work and edited the manuscript.
Informed consent statement: The patient provided informed written consent for study sample collection, as well as permission for their use in research.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Zheng-Qiang Wei, MD, Doctor, Lecturer, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuanjiagang, Chongqing 400000, China. 384535713@qq.com
Received: July 12, 2020 Peer-review started: July 12, 2020 First decision: September 24, 2020 Revised: October 2, 2020 Accepted: October 27, 2020 Article in press: October 27, 2020 Published online: December 6, 2020 Processing time: 145 Days and 1.8 Hours
Abstract
BACKGROUND
Small-cell neuroendocrine carcinoma (SNEC) of the rectum is a rare tumor associated with poor prognosis.
CASE SUMMARY
We report a case of a 77-year-old male who came into our hospital because of blood with his stool. An endoscopy revealed a cauliflower-like neoplasm in his rectum. Imaging examination showed that the lesion in the upper rectum was likely rectal cancer, and there was no evidence of metastasis. The patient was treated with surgery. Pathological examination confirmed SNEC of the rectum and an R0 resection was achieved. However, 1 mo after the operation, the patient developed intestinal and ureteral obstructions due to peritoneal metastases. Finally, the patient died from renal failure.
CONCLUSION
SNEC of the rectum is a high-grade carcinoma with an aggressive phenotype, and surgery should be cautiously considered.
Core Tip: Total mesorectal excision was performed according to pathological analysis, and R0 resection was achieved. However, this patient had tumor recurrence only 1 mo after surgery. Therefore, small-cell neuroendocrine carcinoma of the rectum is a high-grade carcinoma with an aggressive phenotype.
