Hao FY, Wang YL, Li SM, Xue LF. Sebaceous lymphadenocarcinoma of the parotid gland: A case report. World J Clin Cases 2020; 8(22): 5751-5757 [PMID: 33344570 DOI: 10.12998/wjcc.v8.i22.5751]
Corresponding Author of This Article
Ling-Fa Xue, MD, Associate Chief Physician, Department of Oral and Maxillofacial Surgery, The Affiliated Hospital of Qingdao University, No. 1677 Wutaishan Road, Qingdao 266555, Shandong Province, China. xuelingfa@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Feng-Yun Hao, Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao 266555, Shandong Province, China
Yan-Li Wang, Department of Operating Room, The Affiliated Hospital of Qingdao University, Qingdao 266555, Shandong Province, China
Shao-Ming Li, Ling-Fa Xue, Department of Oral and Maxillofacial Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266555, Shandong Province, China
Author contributions: Hao FY performed the pathological imaging, carried out the histopathological studies, and edited the final version; Xue LF obtained the medical history, searched and reviewed the literature, drafted the manuscript, and edited the final version; Wang YL obtained patient follow-up information; Li SM obtained the medical history, provided diagnostic consultation, managed the patient, and edited the final version of the manuscript; All authors read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ling-Fa Xue, MD, Associate Chief Physician, Department of Oral and Maxillofacial Surgery, The Affiliated Hospital of Qingdao University, No. 1677 Wutaishan Road, Qingdao 266555, Shandong Province, China. xuelingfa@163.com
Received: August 10, 2020 Peer-review started: August 10, 2020 First decision: September 13, 2020 Revised: September 23, 2020 Accepted: September 26, 2020 Article in press: September 26, 2020 Published online: November 26, 2020 Processing time: 107 Days and 6.2 Hours
Abstract
BACKGROUND
Sebaceous lymphadenoma is a benign tumor that occurs rarely in the salivary glands, most commonly in the parotid glands or periparotid lymph nodes, and even more rarely undergoes malignant transformation into a sebaceous lymphadenocarcinoma.
CASE SUMMARY
We report an 82-year-old woman who presented with a painless mass in the right parotid region. We performed extended surgical resection of the parotid gland mass. Intraoperative pathology revealed a sebaceous lymphadenocarcinoma with metastasis into the periparotid cervical lymph nodes, so we also performed neck dissection and lymph node resection. Postoperative pathology confirmed the diagnosis. The literature review revealed that this was the seventh reported case of sebaceous lymphadenocarcinoma and the second reported case of cervical lymph node metastasis and infiltration of the skin of the parotid gland.
CONCLUSION
Treatment of sebaceous lymphadenocarcinoma depends on the typing and clinical staging of the cancer. Extensive resection is the first choice, and adjuvant radiotherapy should be given to patients with high-grade tumors or those at an advanced clinical stage.
Core Tip: We present a case of sebaceous lymphadenocarcinoma in the parotid gland of an elderly woman, with metastases to the periparotid lymph nodes. Because these tumors are so rare, we conducted a literature review of sebaceous lymphadenocarcinoma, which revealed that our case is only the seventh reported case of sebaceous lymphadenocarcinoma and the second with cervical lymph node metastasis and infiltration of the skin of the parotid gland. We believe that because these tumors are rare, our case report will add valuable information to the growing reports of their occurrence.
