Song X, Yang J, Lai Y, Zhou J, Wang J, Sun X, Wang D. Localized amyloidosis affecting the lacrimal sac managed by endoscopic surgery: A case report. World J Clin Cases 2020; 8(22): 5684-5689 [PMID: 33344561 DOI: 10.12998/wjcc.v8.i22.5684]
Corresponding Author of This Article
De-Hui Wang, MD, PhD, Professor, Department of Otorhinolaryngology, Eye, Ear, Nose, and Throat Hospital, Fudan University, No. 83 Fenyang Road, Shanghai 200031, China. wangdehuient@sina.com
Research Domain of This Article
Otorhinolaryngology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Xiao-Le Song, Jing-Yi Yang, Yu-Ting Lai, Jia-Ying Zhou, Jing-Jing Wang, Xi-Cai Sun, De-Hui Wang, Department of Otorhinolaryngology, Eye, Ear, Nose, and Throat Hospital, Fudan University, Shanghai 200031, China
Author contributions: Song XL and Yang JY contributed equally to this work; Song XL and Wang DH designed the research study; Song XL wrote the manuscript; Yang JY conducted immunochemistry examination and gave experimental advice; Lai YT and Zhou JY collected the clinical information; Wang JJ and Sun XC revised the manuscript; all authors have read and approved the final manuscript.
Supported bythe General Program of Shanghai Municipal Health Commission, No. 201940143; and Youth Program of National Nature Science Foundation of China, No. 81800897.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: De-Hui Wang, MD, PhD, Professor, Department of Otorhinolaryngology, Eye, Ear, Nose, and Throat Hospital, Fudan University, No. 83 Fenyang Road, Shanghai 200031, China. wangdehuient@sina.com
Received: June 18, 2020 Peer-review started: June 18, 2020 First decision: September 23, 2020 Revised: October 1, 2020 Accepted: October 20, 2020 Article in press: October 20, 2020 Published online: November 26, 2020 Processing time: 160 Days and 13.2 Hours
Abstract
BACKGROUND
Here we present a rare case of localized amyloidosis involving the nasolacrimal duct and lacrimal sac which was managed by endoscopic surgery.
CASE SUMMARY
A 50-year-old man whose medical history included bilateral ventricular fold and vocal cord amyloidosis complained of bilateral epiphora. Magnetic resonance imaging revealed a neoplasm within the nasolacrimal sac. Characteristic positivity for Congo red staining and birefringence under a polarized microscope proved the diagnosis of amyloidosis. Dacryocystorhinostomy via an endoscope obtained a favorable result. A one-year follow-up found no recurrence.
CONCLUSION
There are few reports on amyloidosis involving the lacrimal outflow system, and management and outcome are not clear. Endoscopic dacryocystorhinostomy can be a choice to relieve symptoms. Regular follow-up and monitoring of systemic diseases are highly recommended.
Core Tip: A 50-year-old man was admitted with bilateral epiphora for 2 years and an enlargement of the lacrimal sac in his left eye for 3 mo. His medical history included bilateral ventricular fold and vocal cord amyloidosis followed by a neoplasm of the tongue base. Pathological examinations showed positive congo red staining with apple-green birefringence under polarized light. Endoscopic left dacryocystorhinostomy was performed to remove the mass in the nasolacrimal duct and lacrimal sac and achieved no recurrence during 1-year follow-up. Regular follow-up and monitoring of systemic diseases are highly recommended.
