Case Report
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 26, 2020; 8(22): 5639-5644
Published online Nov 26, 2020. doi: 10.12998/wjcc.v8.i22.5639
Gastric plexiform fibromyxoma: A case report
Jin-Yu Pei, Bin Tan, Peng Liu, Guang-Hua Cao, Zu-Sen Wang, Lin-Lin Qu
Jin-Yu Pei, Bin Tan, Peng Liu, Guang-Hua Cao, Zu-Sen Wang, Lin-Lin Qu, Department of Hepatopancreatobiliary Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266555, Shandong Province, China
Jin-Yu Pei, Peng Liu, Guang-Hua Cao, Medical College, Qingdao University, Qingdao 266071, Shandong Province, China
Author contributions: Pei JY contributed to the acquisition, analysis, and interpretation of patient data and drafting of the manuscript; Tan B, Liu P and Cao GH contributed to the acquisition of patient data and finalizing the manuscript; Qu LL and Wang ZS gave final approval of the article; all authors have read and approved the final manuscript.
Informed consent statement: Informed consent was obtained from the patient.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lin-Lin Qu, FRCS (Gen Surg), MD, PhD, Chief Doctor, Department of Hepatopancreatobiliary Surgery, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Huangdao District, Qingdao 266555, Shandong Province, China. taxue9455@sina.com
Received: May 30, 2020
Peer-review started: May 30, 2020
First decision: June 13, 2020
Revised: June 16, 2020
Accepted: September 12, 2020
Article in press: September 12, 2020
Published online: November 26, 2020
Processing time: 179 Days and 4.5 Hours
Abstract
BACKGROUND

Plexiform fibromyxoma (PF) is a rare mesenchymal tumor of the stomach. The clinical features of PF frequently include upper abdominal pain, abdominal discomfort, hematemesis, melena, pyloric obstruction and an upper abdominal mass. We herein report a case of PF resected by laparoscopic radical distal gastrectomy plus Roux-en-Y gastrojejunostomy.

CASE SUMMARY

The patient was admitted to hospital, due to a 1-wk history of an abdominal space-occupying lesion identified during a health examination. He underwent complete resection by laparoscopic radical distal gastrectomy plus Roux-en-Y gastrojejunostomy. During the operation, the tumor was located in the anterior wall of the gastric antrum (approximately 7 cm × 6 cm × 5.5 cm) and did not show evidence of invasion of the serosa. Histology showed that the tumor cells were oval fibroblast-like and spindle-shaped cells, with numerous thin-walled blood vessels and abundant myxoid stroma. Cellular atypia and mitosis were both rare. Immunohistochemistry showed that the tumor cells were immunoreactive for smooth muscle actin, S-100 and CD-10, but were negative for CD-117, CD-34, DOG-1, and ALK. In this case, S-100 was positive and no significant disease was observed during the follow-up period.

CONCLUSION

The fact that PF is a rare tumor with only a few cases in this region can lead to misdiagnosis of this entity and pose a real diagnostic challenge for general surgeons and pathologists when encountering such patients and differentiating PF from other primary tumors of gastric mesenchymal origin. Our report may help increase awareness of this rare, but important new disease entity.

Keywords: Gastric plexiform fibromyxoma; Plexiform fibromyxoma; Immunohistochemistry; Operation; Mesenchymal tumors of stomach; Stomach; Case report

Core Tip: Gastric plexiform fibromyxoma (PF) is a rare gastrointestinal mesenchymal tumor. We report a case of gastric PF, and the clinical manifestations and pathological characteristics of the tumor are summarized in conjunction with a literature review to improve the understanding of this tumor.