Li Q, Xu XZ, Shi JH. Synchronous parathyroid adenoma, papillary thyroid carcinoma and thyroid adenoma in pregnancy: A case report. World J Clin Cases 2020; 8(21): 5426-5431 [PMID: 33269280 DOI: 10.12998/wjcc.v8.i21.5426]
Corresponding Author of This Article
Jian-Hua Shi, MD, Associate Professor, Chief Doctor, Surgeon, Department of Breast and Thyroid Surgery, the Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, No. 1 Huanghe Road West, Huai'an 223300, Jiangsu Province, China. jianhuashi@163.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Nov 6, 2020; 8(21): 5426-5431 Published online Nov 6, 2020. doi: 10.12998/wjcc.v8.i21.5426
Synchronous parathyroid adenoma, papillary thyroid carcinoma and thyroid adenoma in pregnancy: A case report
Qiang Li, Xiao-Zhang Xu, Jian-Hua Shi
Qiang Li, Xiao-Zhang Xu, Jian-Hua Shi, Department of Breast and Thyroid Surgery, The Affiliated Huaian No. 1 People’s Hospital of Nanjing Medical University, Huai'an 223300, Jiangsu Province, China
Author contributions: Li Q examined the patient and collected clinical data; Shi JH and Li Q performed the surgical resection and follow-up; Li Q and Xu XZ wrote the paper; Xu XZ collected pathological images; Shi JH and Li Q edited the manuscript and provided final approval.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian-Hua Shi, MD, Associate Professor, Chief Doctor, Surgeon, Department of Breast and Thyroid Surgery, the Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, No. 1 Huanghe Road West, Huai'an 223300, Jiangsu Province, China. jianhuashi@163.com
Received: April 15, 2020 Peer-review started: April 15, 2020 First decision: April 24, 2020 Revised: September 8, 2020 Accepted: September 16, 2020 Article in press: September 16, 2020 Published online: November 6, 2020 Processing time: 204 Days and 17 Hours
Abstract
BACKGROUND
There is a common pathologic relationship between parathyroid adenoma and thyroid cancer, but this relationship is infrequent in pregnant patients with primary hyperparathyroidism (PHPT).
CASE SUMMARY
A 27-year-old gravida 1 woman was transferred to our hospital at 16 wk of pregnancy. She was diagnosed with parathyroidoma, papillary carcinoma of the thyroid and thyroid adenoma and was managed surgically. Both the mother and the newborn were stable after a right inferior parathyroidectomy and total thyroidectomy. The healthy infant was delivered at the 40th week of pregnancy. The mother had no evidence of recurrence over three years of follow-up.
CONCLUSION
Awareness of concomitant PHPT and thyroid diseases may help in managing patients with a history of hypercalcemia.
Core Tip: Primary hyperparathyroidism (PHPT) with parathyroid adenoma associated with papillary cancer and adenoma of the thyroid is unusual. The preliminary test results showed severe hypercalcemia. The level of parathyroid hormone found in further laboratory tests was elevated and a diagnosis of PHPT was determined. Right lower parathyroid gland and total thyroidectomy were performed. This clinical case illustrates the need for awareness of concomitant PHPT and thyroid diseases.
