Zhou HY, Jiang S, Ma FX, Lu H. Peripheral nerve tumors of the hand: Clinical features, diagnosis, and treatment. World J Clin Cases 2020; 8(21): 5086-5098 [PMID: 33269245 DOI: 10.12998/wjcc.v8.i21.5086]
Corresponding Author of This Article
Hui Lu, MD, Attending Doctor, Department of Orthopedics, Zhejiang University, Department of Hand Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. huilu@zju.edu.cn
Research Domain of This Article
Oncology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Nov 6, 2020; 8(21): 5086-5098 Published online Nov 6, 2020. doi: 10.12998/wjcc.v8.i21.5086
Peripheral nerve tumors of the hand: Clinical features, diagnosis, and treatment
Hai-Ying Zhou, Shuai Jiang, Fei-Xia Ma, Hui Lu
Hai-Ying Zhou, Shuai Jiang, Hui Lu, Department of Orthopedics, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Fei-Xia Ma, Department of Breast Surgery, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310000, Zhejiang Province, China
Author contributions: Ma FX and Zhou HY contributed to the literature search and study design; Jiang S contributed to study conception and manuscript writing; Lu H contributed to study design and manuscript revision; All authors have read and approved the final manuscript.
Supported bythe National Natural Science Foundation of China, No. 81702135; Natural Science Foundation of Zhejiang Province, No. LQ20H060008 and No. LY20H060007; and Zhejiang Medicine and Hygiene Research Program, No. 2018KY055.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hui Lu, MD, Attending Doctor, Department of Orthopedics, Zhejiang University, Department of Hand Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. huilu@zju.edu.cn
Received: May 20, 2020 Peer-review started: May 20, 2020 First decision: September 14, 2020 Revised: September 15, 2020 Accepted: September 25, 2020 Article in press: September 25, 2020 Published online: November 6, 2020 Processing time: 170 Days and 5.3 Hours
Abstract
The majority of the tumors arising from the peripheral nerves of the hand are relatively benign. However, a tumor diagnosed as malignant peripheral nerve sheath tumor (MPNST) has destructive consequences. Clinical signs and symptoms are usually caused by direct and indirect effects of the tumor, such as nerve invasion or compression and infiltration of surrounding tissues. Definitive diagnosis is made by tumor biopsy. Complete surgical removal with maximum reservation of residual neurologic function is the most appropriate intervention for most symptomatic benign peripheral nerve tumors (PNTs) of the hand; however, MPNSTs require surgical resection with a sufficiently wide margin or even amputation to improve prognosis. In this article, we review the clinical presentation and radiographic features, summarize the evidence for an accurate diagnosis, and discuss the available treatment options for PNTs of the hand.
Core Tip: Tumors located within a peripheral nerve are rare and easily overlooked. In this paper, we review clinical presentation and radiographic features, summarize the evidence for accurate diagnosis, and discuss available treatment options for peripheral nerve tumors arising in the hand.
