Case Report
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 26, 2020; 8(2): 398-403
Published online Jan 26, 2020. doi: 10.12998/wjcc.v8.i2.398
Cryoablation for liver metastasis from solid pseudopapillary tumor of the pancreas: A case report
Yang-Yang Ma, Ji-Bing Chen, Juan-Juan Shi, Li-Zhi Niu, Ke-Chen Xu
Yang-Yang Ma, Ji-Bing Chen, Central Laboratory, Fuda Cancer Hospital, Jinan University, Guangzhou 510665, Guangdong Province, China
Juan-Juan Shi, Li-Zhi Niu, Ke-Chen Xu, Department of Oncology, Fuda Cancer Hospital, Jinan University, Guangzhou 510665, Guangdong Province, China
Author contributions: Niu LZ and Xu KC designed the research; Shi JJ and Niu LZ performed the research; Chen JB analyzed the data; Ma YY wrote the paper.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Ke-Chen Xu, MD, PhD, Chairman, Department of Oncology, Fuda Cancer Hospital, Jinan University, No. 2, Tangde Road, Tianhe District, Guangzhou 510665, Guangdong Province, China. xukc@vip.163.com
Received: October 29, 2019
Peer-review started: October 29, 2019
First decision: November 22, 2019
Revised: December 16, 2019
Accepted: December 22, 2019
Article in press: December 22, 2019
Published online: January 26, 2020
Processing time: 79 Days and 16.3 Hours
Abstract
BACKGROUND

Solid pseudopapillary tumor (SPT) of the pancreas is a rare pancreatic tumor and 10% to 15% of cases are associated with metastasis. Cryoablation is a new method that can induce tumor necrosis, and treatment of tumors by cryoablation can cause anti-tumor immune responses.

CASE SUMMARY

A 16-year-old woman with SPT of the pancreas developed liver metastases 5.3 years after complete resection of the primary pancreatic tumor. She was admitted with chief complaints of abdominal pain in the upper abdomen and a weight loss of approximately 5 kg over 4 mo. Carbohydrate antigen (CA) 125, carcinoembryonic antigen, and CA 199 were normal. An abdominal computed tomography scan found multiple nodules in the right lobe of the liver that measured approximately 13.5 cm × 10.8 cm × 21.4 cm. Immunohistochemical staining results showed that CD10 and CD56 were positive, and the patient was diagnosed with SPT of the pancreas with liver metastasis. The patient underwent percutaneous cryoablation and interventional embolization. During the 5-year follow-up, the patient remained disease-free after cryoablation, with relatively normal immune function.

CONCLUSION

Herein, we for the first time report the treatment of liver metastasis from SPT of the pancreas using cryoablation plus interventional embolization, which could be a promising alternative therapy for pancreatic SPT liver metastasis.

Keywords: Solid pseudopapillary tumor; Pancreas; Liver metastasis; Cryoablation; Interventional embolization; Case report

Core tip: In this study, we report the case of a 16-year-old female patient with solid pseudopapillary tumor (SPT) of the pancreas with liver metastasis who obtained a favorable outcome after combined cryoablation and transcatheter arterial embolization treatment. Our study showed that SPT liver metastasis is rare and occurs at various time points after diagnosis. Cryoablation with transcatheter arterial embolization could be utilized as an alternative therapy for pancreatic SPT liver metastasis.