Han XY, Wang YY, Wei HQ, Yang GZ, Wang J, Jia YZ, Ao WQ. Multifocal neuroendocrine cell hyperplasia accompanied by tumorlet formation and pulmonary sclerosing pneumocytoma: A case report. World J Clin Cases 2020; 8(16): 3583-3590 [PMID: 32913868 DOI: 10.12998/wjcc.v8.i16.3583]
Corresponding Author of This Article
Wei-Qun Ao, MD, Doctor, Radiologist, Department of Radiology, Tongde Hospital of Zhejiang Province, No. 234 Gucui Road, Hangzhou 310012, Zhejiang Province, China. 78123858@qq.com
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Xiao-Yu Han, Yuan-Yuan Wang, Hong-Quan Wei, Department of Pathology, Tongde Hospital of Zhejiang Province, Hangzhou 310012, Zhejiang Province, China
Guang-Zhao Yang, Jian Wang, Yu-Zhu Jia, Wei-Qun Ao, Department of Radiology, Tongde Hospital of Zhejiang Province, Hangzhou 310012, Zhejiang Province, China
Author contributions: Han XY, Jia YZ, Wei HQ, Wang J, and Wang YY were responsible for the collection and analysis of the patient’s data; Ao WQ and Han XY drafted the manuscript; Ao WQ and Yang GZ performed the manuscript editing and revising.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Wei-Qun Ao, MD, Doctor, Radiologist, Department of Radiology, Tongde Hospital of Zhejiang Province, No. 234 Gucui Road, Hangzhou 310012, Zhejiang Province, China. 78123858@qq.com
Received: February 18, 2020 Peer-review started: February 18, 2020 First decision: July 4, 2020 Revised: July 6, 2020 Accepted: July 16, 2020 Article in press: July 16, 2020 Published online: August 26, 2020 Processing time: 189 Days and 3.4 Hours
Abstract
BACKGROUND
Pulmonary tumorlets are nodular hyperplastic neuroendocrine cells (NECs) that extend beyond the basement membrane. They often coexist with other lung diseases such as fibrosis and bronchiectasis, but rarely accompanied by pulmonary sclerosing pneumocytoma (PSP), which has not been reported in the literature.
CASE SUMMARY
A 54-year-old woman was admitted to the hospital because she had symptoms of bloody sputum for more than 4 mo and hemoptysis for 1 wk. Computed tomography images showed atrophy accompanied by infections in the middle lobe of her right lung. Moreover, numerous nodules were identified in the middle lobe of the right lung. The patient underwent thoracoscopic pneumonectomy of the middle lobe of the right lung, and the resected mass was pathologically confirmed to have bronchiectasis, multifocal NEC hyperplasia accompanied by tumorlet, and PSP.
CONCLUSION
Our report presents a rare clinical case of bronchiectasis complicated with multifocal NEC hyperplasia, tumorlet, and PSP.
Core tip: Pulmonary tumorlets are nodular hyperplastic neuroendocrine cells that extend beyond the basement membrane. They often coexist with other lung diseases such as fibrosis and bronchiectasis, but rarely accompanied by pulmonary sclerosing pneumocytoma. This paper reports a rare clinical case of bronchiectasis complicated with multifocal nodular hyperplastic neuroendocrine cell hyperplasia, tumorlet, and pulmonary sclerosing pneumocytoma. The patient was followed after computed tomography scanning and received surgical resection. We observed the progression of the tumor that has not yet been reported, which can be of great value in the diagnosis of the disease.
