Li YP, Yang Y, Wang MQ, Zhang X, Wang WJ, Li M, Wu FP, Dang SS. Facial and bilateral lower extremity edema due to drug-drug interactions in a patient with hepatitis C virus infection and benign prostate hypertrophy: A case report. World J Clin Cases 2020; 8(15): 3372-3376 [PMID: 32874995 DOI: 10.12998/wjcc.v8.i15.3372]
Corresponding Author of This Article
Shuang-Suo Dang, PhD, Professor, Department of Infectious Diseases, Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 Xiwu Road, Xincheng District, Xi'an 710004, Shaanxi Province, China. dangshuangsuo123@xjtu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Aug 6, 2020; 8(15): 3372-3376 Published online Aug 6, 2020. doi: 10.12998/wjcc.v8.i15.3372
Facial and bilateral lower extremity edema due to drug-drug interactions in a patient with hepatitis C virus infection and benign prostate hypertrophy: A case report
Ya-Ping Li, Ying Yang, Mu-Qi Wang, Xin Zhang, Wen-Jun Wang, Mei Li, Feng-Ping Wu, Shuang-Suo Dang, Department of Infectious Diseases, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
Author contributions: Li YP and Yang Y were the patient’s doctor in charge, reviewed the literature and contributed to manuscript drafting; Wang MQ, Zhang X and Wang WJ reviewed the literature and contributed to manuscript drafting; Li M, Wu FP and Dang SS revised the manuscript for important intellectual content; all authors issued final approval for the version to be submitted.
Supported bythe National Natural Science Foundation of China, No. 81701632; Shanxi Province Social Development Project, No. 2018SF-269.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Shuang-Suo Dang, PhD, Professor, Department of Infectious Diseases, Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 Xiwu Road, Xincheng District, Xi'an 710004, Shaanxi Province, China. dangshuangsuo123@xjtu.edu.cn
Received: March 18, 2020 Peer-review started: March 18, 2020 First decision: April 22, 2020 Revised: June 7, 2020 Accepted: July 16, 2020 Article in press: July 16, 2020 Published online: August 6, 2020 Processing time: 140 Days and 20.5 Hours
Abstract
BACKGROUND
New direct-acting antivirals (DAAs)-based anti-hepatitis C virus (HCV) therapies are highly effective in patients with HCV infection. However, safety data are lacking regarding HCV treatment with DAAs and drugs for comorbidities.
CASE SUMMARY
Herein, we reported a case of HCV-infection in a 46-year-old man with benign prostatic hypertrophy. The patient received sofosbuvir/velpatasvir as well as methadone maintenance therapy for drug abuse. The viral load became negative at week 1 post treatment. He developed facial and bilateral lower extremity edema 48 h after starting receiving tamsulosin. Edema disappeared 10 d after treatment with oral furosemide and spironolactone.
CONCLUSION
In conclusion, this is the first case of an acute edema in the course of treatment with new DAAs, methadone and tamsulosin. These agents are useful in clinical management of patients with HCV infection, particularly in men with benign prostatic hypertrophy. Clinicians should be aware of potential drug-drug interactions in this subset of patients.
Core tip: In this manuscript, we report a case of drug-drug interaction in a 46-year-old man who was diagnosed with hepatitis C virus infection with benign prostatic hypertrophy. The patient received sofosbuvir/velpatasvir as well as methadone maintenance therapy for drug abuse. The viral load became negative at week 1 post treatment. He developed facial and bilateral lower extremity edema 48 h after starting receiving tamsulosin. Edema disappeared 10 d after treatment with oral furosemide and spironolactone. This case could be useful in clinical management of patients with hepatitis C virus infection, and clinicians should be aware of drug-drug interactions in this subset of patients.
