Yang F, Zhao ZC, Hu AJ, Sun PF, Zhang B, Yu MC, Wang J. Synchronous sporadic bilateral multiple chromophobe renal cell carcinoma accompanied by a clear cell carcinoma and a cyst: A case report. World J Clin Cases 2020; 8(14): 3064-3073 [PMID: 32775388 DOI: 10.12998/wjcc.v8.i14.3064]
Corresponding Author of This Article
Bin Zhang, BM BCh, Associate Professor, Department of Radiology, Peking University Shougang Hospital, No. 9, Jinyuanzhuang Road, Shijingshan District, Beijing 100144, China. zhangbinsgyy@126.com
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jul 26, 2020; 8(14): 3064-3073 Published online Jul 26, 2020. doi: 10.12998/wjcc.v8.i14.3064
Synchronous sporadic bilateral multiple chromophobe renal cell carcinoma accompanied by a clear cell carcinoma and a cyst: A case report
Fan Yang, Zi-Chen Zhao, A-Jin Hu, Peng-Fei Sun, Bin Zhang, Ming-Chuan Yu, Juan Wang
Fan Yang, Bin Zhang, Ming-Chuan Yu, Juan Wang, Department of Radiology, Peking University Shougang Hospital, Beijing 100144, China
Zi-Chen Zhao, Department of Urinary Surgery, Peking University Shougang Hospital, Beijing 100144, China
A-Jin Hu, Department of Pathology, Peking University Shougang Hospital, Beijing 100144, China
Peng-Fei Sun, Department of Ultrasound, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
Author contributions: Zhao ZC was the patient’s surgeon, reviewed the literature, and contributed to manuscript drafting; Hu AJ performed the pathology analyses and interpretation and contributed to manuscript drafting; Yu MC and Wang J analyzed and interpreted the imaging findings; Yang F and Sun PF reviewed the literature and contributed to the manuscript; Yang F and Zhang B were responsible for the revision of the manuscript for important intellectual content; All authors issued final approval for the version to be submitted.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Bin Zhang, BM BCh, Associate Professor, Department of Radiology, Peking University Shougang Hospital, No. 9, Jinyuanzhuang Road, Shijingshan District, Beijing 100144, China. zhangbinsgyy@126.com
Received: March 19, 2020 Peer-review started: March 19, 2020 First decision: April 22, 2020 Revised: May 1, 2020 Accepted: June 25, 2020 Article in press: June 25, 2020 Published online: July 26, 2020 Processing time: 126 Days and 21.9 Hours
Abstract
BACKGROUND
Renal cell carcinomas are usually unilateral. However, they are bilateral in 2% to 4% of sporadic cases and is considerably more common in familial cases. Synchronous sporadic bilateral multiple chromophobe renal cell carcinoma (CHRCC) with different subtypes is rare.
CASE SUMMARY
In this case report, we describe a case of synchronous bilateral CHRCC with two histological variants, accompanied by a clear cell carcinoma and a cyst in a 50-year-old male. The patient underwent retroperitoneal laparoscopic bilateral nephron-sparing surgery and there was no serious postoperative renal dysfunction.
CONCLUSION
We report a rare case of synchronous bilateral CHRCC with two histological variants associated with a clear cell carcinoma and a cyst.
Core tip: Synchronous sporadic bilateral multiple chromophobe renal cell carcinoma (CHRCC) is rare. We present an incidentally detected case of synchronous occurrence of bilateral CHRCC. This case had two concomitant different subtypes of CHRCC in each kidney (classic type and eosinophilic type), accompanied by a clear cell carcinoma and a cyst. The patient underwent retroperitoneal laparoscopic bilateral nephron-sparing surgery and there was no serious postoperative renal dysfunction.
