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Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 6, 2020; 8(13): 2717-2726
Published online Jul 6, 2020. doi: 10.12998/wjcc.v8.i13.2717
Relevance on the diagnosis of malignant lymphoma of the salivary gland
Xin-Yue Zhang, Zhi-Ming Wang
Xin-Yue Zhang, Zhi-Ming Wang, Department of Stomatology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Author contributions: Zhang XY contributed to the majority of the writing; Wang ZM performed the Table and edited the article.
Supported by the 345 Talent Project of Shengjing Hospital; and the Natural Science Foundation of Liaoning Province, No. 20170541042.
Conflict-of-interest statement: No potential conflicts of interest. No financial support.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Zhi-Ming Wang, DDS, MD, PhD, Chief Doctor, Professor, Surgeon, Department of Stomatology, Shengjing Hospital of China Medical University, No. 36, Sanhao Distreet, Heping District, Shenyang 110004, Liaoning Province, China. wangzm@sj-hospital.org
Received: February 20, 2020
Peer-review started: February 20, 2020
First decision: April 9, 2020
Revised: April 13, 2020
Accepted: June 10, 2020
Article in press: June 10, 2020
Published online: July 6, 2020
Processing time: 137 Days and 12.3 Hours
Abstract

Malignant lymphoma originates from the lymphohematopoietic system. It can occur in any lymphoid tissue. Malignant lymphoma of the salivary gland is rare, but its incidence has increased in recent years. Its clinical- presentations are non-specific, and it is often manifested as a painless mass in a salivary gland, which can be accompanied by multiple swollen cervical lymph nodes. Confirmation of the diagnosis before an invasive procedure is difficult. Clinically, malignant lymphoma of the salivary gland tends to be misdiagnosed, leading to an inappropriate treatment plan and the ultimate delay in the optimal treatment of the disease. This article reviews the pathogenesis, clinical features, imaging findings, diagnosis, treatment and prognosis of malignant lymphoma of the salivary gland.

Keywords: Salivary gland; Malignant lymphoma; Pathogenic factors; Clinical features; Diagnosis; Treatment

Core tip: Salivary gland lymphoma (SGL) is rare, and it is often manifested as a painless mass in a salivary gland, with or without multiple swollen cervical lymph nodes. Clinically, SGL tends to be misdiagnosed as other epithelial tumors of the salivary gland, leading to an inappropriate surgical excision and delay in the optimal treatment of the disease. This article reviews the pathogenesis, clinical features, imaging findings, diagnosis, treatment and prognosis of SGL.