Xin Q, Sun Q, Zhang CS, Zhang Q, Li CJ. Functions and mechanisms of chemokine receptor 7 in tumors of the digestive system. World J Clin Cases 2020; 8(12): 2448-2463 [PMID: 32607322 DOI: 10.12998/wjcc.v8.i12.2448]
Corresponding Author of This Article
Chun-Jun Li, PhD, Chief Doctor, Department of Endocrinology, Health Management Center, Tianjin Union Medical Center, Nankai University Affiliated Hospital, 190 Jai-yuan Road, Hong-qiao District, Tianjin 300121, China. li_chunjun@126.com
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jun 26, 2020; 8(12): 2448-2463 Published online Jun 26, 2020. doi: 10.12998/wjcc.v8.i12.2448
Functions and mechanisms of chemokine receptor 7 in tumors of the digestive system
Qi Xin, Quan Sun, Chuan-Shan Zhang, Qin Zhang, Chun-Jun Li
Qi Xin, Chuan-Shan Zhang, Qin Zhang, Department of Pathology, Tianjin Third Central Hospital, The Third Central Clinical College of Tianjin Medical University, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin 300170, China
Qi Xin, Tianjin Key Laboratory of Brain Science and Neural Engineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China
Quan Sun, Department of Hepatobiliary Surgery, Tianjin Third Central Hospital, The Third Central Clinical College of Tianjin Medical University, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin 300170, China
Chun-Jun Li, Department of Endocrinology, Health Management Center, Tianjin Union Medical Center, Nankai University Affiliated Hospital, Tianjin 300121, China
Author contributions: Xin Q and Li CJ wrote the main text; Li CJ, Zhang CS and Zhang Q conceptualized the manuscript; Li CJ and Xin Q designed and generated the figures; Sun Q researched content for the review, discussed the content, and edited the manuscript.
Supported byKey Projects of Tianjin Natural Science Foundation, No. 19JCZDJC36100; General Project of Natural Science Fund of Tianjin Education Commission, No. 2018KJ047; Subject in the Third Affiliated Central Hospital of Nankai University, No. 2017YNY3; Tianjin Key Special Projects, No. 15KG115.
Conflict-of-interest statement: There is no conflict of interest associated with any of the senior author or other coauthors contributed their efforts in this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Chun-Jun Li, PhD, Chief Doctor, Department of Endocrinology, Health Management Center, Tianjin Union Medical Center, Nankai University Affiliated Hospital, 190 Jai-yuan Road, Hong-qiao District, Tianjin 300121, China. li_chunjun@126.com
Received: February 2, 2020 Peer-review started: February 2, 2020 First decision: April 9, 2020 Revised: May 12, 2020 Accepted: June 3, 2020 Article in press: June 3, 2020 Published online: June 26, 2020 Processing time: 143 Days and 3.7 Hours
Abstract
Chemokine (C-X-C motif) receptor 7 (CXCR7), recently termed ACKR3, belongs to the G protein-coupled cell surface receptor family, binds to stromal cell-derived factor-1 [SDF-1, or chemokine (C-X-C motif) ligand 12] or chemokine (C-X-C motif) ligand 11, and is the most common chemokine receptor expressed in a variety of cancer cells. SDF-1 binds to its receptor chemokine (C-X-C motif) receptor 4 (CXCR4) and regulates cell proliferation, survival, angiogenesis and migration. In recent years, another new receptor for SDF-1, CXCR7, has been discovered, and CXCR7 has also been found to be expressed in a variety of tumor cells and tumor-related vascular endothelial cells. Many studies have shown that CXCR7 can promote the growth and metastasis of a variety of malignant tumor cells. Unlike CXCR4, CXCR7 exhibits a slight modification in the DRYLAIV motif and does not induce intracellular Ca2+ release following ligand binding, which is essential for recruiting and activating G proteins. CXCR7 is generally thought to work in three ways: (1) Recruiting β-arrestin 2; (2) Heterodimerizing with CXCR4; and (3) Acting as a “scavenger” of SDF-1, thus lowering the level of SDF-1 to weaken the activity of CXCR4. In the present review, the expression and role of CXCR7, as well as its prognosis in cancers of the digestive system, were investigated.
Core tip: Digestive tract tumors are one of the most important tumors in the whole body. As a newly discovered receptor of stromal cell-derived factor-1, chemokine (C-X-C motif) receptor 7 (CXCR7) has attracted increasing attention from researchers. Over the years, studies have found that CXCR7 is expressed in a variety of malignant tumors of the digestive system and plays an important role in the occurrence, development and metastasis of tumors. Many studies have also shown that CXCR7 can serve as a prognostic factor for a variety of tumors and may be a target for the treatment of a variety of tumors. Here, we summarized all the manifestations and functions of CXCR7 in various gastrointestinal tumors and compared the research status of CXCR7 in different types of gastrointestinal tumors.
