Case Control Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 6, 2020; 8(11): 2144-2149
Published online Jun 6, 2020. doi: 10.12998/wjcc.v8.i11.2144
High flux hemodialysis in elderly patients with chronic kidney failure
Hai-Yan Xue, Bin Duan, Zhen-Jiang Li, Peng Du
Hai-Yan Xue, Dialysis Center, The Fourth People’s Hospital of Shaanxi, Xi’an 710043, Shaanxi Province, China
Bin Duan, Zhen-Jiang Li, Peng Du, Department of Kidney Diseases, Dialysis Center, Shaanxi Provincial People’s Hospital, Xi’an 710068, Shaanxi Province, China
Author contributions: Du P reviewed and edited the manuscript; Xue HY and Li ZJ contributed equally to this manuscript and should be considered as co-first authors; Xue HY, Li ZJ, Duan B, and Du P contributed to study conceptualization, methodology, data collection, data analysis, and article writing; all authors approved the submitted manuscript.
Institutional review board statement: The study was approved by Ethics Committee of The Fourth People’s Hospital of Shaanxi.
Informed consent statement: All patients gave informed consent.
Conflict-of-interest statement: The authors declare that there is no conflict of interest.
Data sharing statement: No additional data available.
STROBE statement: The manuscript has been prepared and revised according to the STROBE statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Peng Du, MD, Chief Physician, Department of Kidney Disease, Dialysis Center, Shaanxi Provincial People’s Hospital, No. 256, Youyi West Road, Beilin District, Xi’an 710068, Shaanxi Province, China. seasonn@163.com
Received: March 22, 2020
Peer-review started: March 22, 2020
First decision: April 14, 2020
Revised: April 29, 2020
Accepted: May 1, 2020
Article in press: May 1, 2020
Published online: June 6, 2020
Abstract
BACKGROUND

Hemodialysis is an advanced blood purification technique to manage kidney failure. However, for conventional hemodialysis, the high prevalence of dyslipidemia may cause cardiovascular diseases and an increase in mortality. Moreover, toxins accumulating in the body over time may induce some complications. High flux hemodialysis can effectively improve disease indexes and clinical symptoms.

AIM

To investigate the efficacy of high flux hemodialysis in elderly patients with chronic kidney failure (CKF).

METHODS

A total of 66 elderly patients with CKF who were admitted to our hospital from October 2017 to October 2018 were included in the study. According to the therapies they received, the patients were divided into a study group and a control group with 33 patients in each group. The study group received high flux hemodialysis and the control group received conventional dialysis treatment. Kidney function, toxin levels in serum, and complications were compared in the two groups.

RESULTS

Before the treatment, there was no significant difference in kidney function, β2-microglobulin, or blood urea nitrogen between the two groups (P > 0.05). In contrast, kidney function was better in the study group than in the control group after the treatment (P < 0.05). In addition, the study group had significantly lower parathyroid hormone and serum cystatin C than the control group (P < 0.05). The incidence of complications was 8.57% in the study group, which was lower than that of the control group (20.00%; P < 0.05).

CONCLUSION

High flux hemodialysis may improve kidney function and reduce toxin levels in serum and the incidence of complications in elderly patients with CKF.

Keywords: Elderly patients, Chronic kidney failure, High flux, Hemodialysis

Core tip: Hemodialysis is an advanced blood purification technique to manage kidney failure. However, for conventional hemodialysis, the high prevalence of dyslipidemia may cause cardiovascular diseases and an increase in mortality. Moreover, toxins accumulating in the body over time may induce some complications. The present study researched high flux hemodialysis in elderly patients with chronic kidney failure. The results revealed that high flux hemodialysis is a highly effective technique to purify the blood. It can effectively remove toxins from the blood and regulate lipids in the blood with lowered incidence of complications.