Qin LF, Liang Y, Xing XM, Wu H, Yang XC, Niu HT. Villous adenoma coexistent with focal well-differentiated adenocarcinoma of female urethral orifice: A case report and review of literature. World J Clin Cases 2019; 7(7): 891-897 [PMID: 31024961 DOI: 10.12998/wjcc.v7.i7.891]
Corresponding Author of This Article
Hai-Tao Niu, MD, Doctor, Professor, Surgeon, Surgical Oncologist, Department of Urology, Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao 266003, Shandong Province, China. niuhttg@163.com
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Lu-Feng Qin, Hui Wu, Department of Medicine, Qingdao University, Qingdao 266003, Shandong Province, China
Lu-Feng Qin, Hui Wu, Xue-Cheng Yang, Hai-Tao Niu, Department of Urology, Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China
Ye Liang, Hai-Tao Niu, Key Laboratory of Urinary System Diseases, Qingdao 266003, Shandong Province, China
Xiao-Ming Xing, Department of Pathology, Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China
Author contributions: Qin LF, Liang Y, Wu H, Yang XC, Xing XM, and Niu HT collected the case data; Qin LF wrote the manuscript; Niu HT revised the manuscript.
Informed consent statement: All patients completed informed consent forms.
Conflict-of-interest statement: None of the authors have a conflict of interest to report.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Hai-Tao Niu, MD, Doctor, Professor, Surgeon, Surgical Oncologist, Department of Urology, Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao 266003, Shandong Province, China. niuhttg@163.com
Telephone: +86-532-82911953
Received: December 3, 2018 Peer-review started: December 6, 2018 First decision: December 15, 2018 Revised: January 2, 2019 Accepted: January 26, 2019 Article in press: January 26, 2019 Published online: April 6, 2019 Processing time: 123 Days and 19.6 Hours
Abstract
BACKGROUND
Villous adenomas of the urinary tract are uncommon. They are morphologically similar to and difficult to differentiate from their counterpart in the colon. The histogenesis and malignant potential are uncertain.
CASE SUMMARY
A 63-year-old woman was admitted to our hospital with a mass in the urethral orifice. Gross and microscopic pathological examination was suggestive of urethral villous adenoma with focal well-differentiated adenocarcinoma. The whole urethra and part of the bladder were excised. No further treatment was offered. Carcinoembryonic antigen, cytokeratin 7, cytokeratin 20, epithelial membrane antigen, and p53 protein were positive, and the ratio of Ki-67 was 60%. After follow-up at 11 mo, the patient was cured and had no recurrence.
CONCLUSION
Immunohistochemistry is important for differential diagnosis of villous adenoma of the urinary system. Complete surgical resection of the urinary tract is curative.
Core tip: Villous adenoma coexisting with adenocarcinoma of the urinary system is uncommon. Differential diagnosis from villous adenoma of the digestive tract is difficult. We present a case of villous adenoma coexisting with adenocarcinoma of the female urethral orifice and provide an accurate method to differentiate villous adenomas of the urinary and digestive tracts.
