Case Report
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 6, 2019; 7(7): 891-897
Published online Apr 6, 2019. doi: 10.12998/wjcc.v7.i7.891
Villous adenoma coexistent with focal well-differentiated adenocarcinoma of female urethral orifice: A case report and review of literature
Lu-Feng Qin, Ye Liang, Xiao-Ming Xing, Hui Wu, Xue-Cheng Yang, Hai-Tao Niu
Lu-Feng Qin, Hui Wu, Department of Medicine, Qingdao University, Qingdao 266003, Shandong Province, China
Lu-Feng Qin, Hui Wu, Xue-Cheng Yang, Hai-Tao Niu, Department of Urology, Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China
Ye Liang, Hai-Tao Niu, Key Laboratory of Urinary System Diseases, Qingdao 266003, Shandong Province, China
Xiao-Ming Xing, Department of Pathology, Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China
Author contributions: Qin LF, Liang Y, Wu H, Yang XC, Xing XM, and Niu HT collected the case data; Qin LF wrote the manuscript; Niu HT revised the manuscript.
Informed consent statement: All patients completed informed consent forms.
Conflict-of-interest statement: None of the authors have a conflict of interest to report.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Hai-Tao Niu, MD, Doctor, Professor, Surgeon, Surgical Oncologist, Department of Urology, Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao 266003, Shandong Province, China. niuhttg@163.com
Telephone: +86-532-82911953
Received: December 3, 2018
Peer-review started: December 6, 2018
First decision: December 15, 2018
Revised: January 2, 2019
Accepted: January 26, 2019
Article in press: January 26, 2019
Published online: April 6, 2019
Abstract
BACKGROUND

Villous adenomas of the urinary tract are uncommon. They are morphologically similar to and difficult to differentiate from their counterpart in the colon. The histogenesis and malignant potential are uncertain.

CASE SUMMARY

A 63-year-old woman was admitted to our hospital with a mass in the urethral orifice. Gross and microscopic pathological examination was suggestive of urethral villous adenoma with focal well-differentiated adenocarcinoma. The whole urethra and part of the bladder were excised. No further treatment was offered. Carcinoembryonic antigen, cytokeratin 7, cytokeratin 20, epithelial membrane antigen, and p53 protein were positive, and the ratio of Ki-67 was 60%. After follow-up at 11 mo, the patient was cured and had no recurrence.

CONCLUSION

Immunohistochemistry is important for differential diagnosis of villous adenoma of the urinary system. Complete surgical resection of the urinary tract is curative.

Keywords: Villous adenoma, Well-differentiated adenocarcinoma, Urinary tract, Immunohistochemistry, Case report

Core tip: Villous adenoma coexisting with adenocarcinoma of the urinary system is uncommon. Differential diagnosis from villous adenoma of the digestive tract is difficult. We present a case of villous adenoma coexisting with adenocarcinoma of the female urethral orifice and provide an accurate method to differentiate villous adenomas of the urinary and digestive tracts.