Wang DD, Yang Q. Synchronous quadruple primary malignancies of the cervix, endometrium, ovary, and stomach in a single patient: A case report and review of literature. World J Clin Cases 2019; 7(20): 3364-3371 [PMID: 31667193 DOI: 10.12998/wjcc.v7.i20.3364]
Corresponding Author of This Article
Qing Yang, MD, PhD, Professor, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. yangqing_sj@126.com
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Oct 26, 2019; 7(20): 3364-3371 Published online Oct 26, 2019. doi: 10.12998/wjcc.v7.i20.3364
Synchronous quadruple primary malignancies of the cervix, endometrium, ovary, and stomach in a single patient: A case report and review of literature
Dan-Dan Wang, Qing Yang
Dan-Dan Wang, Qing Yang, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Author contributions: Wang DD was responsible for the data collection and drafting of the manuscript; Yang Q was responsible for critical revision of the manuscript; all authors read and approved the final manuscript.
Supported byGrants from the Outstanding Scientific Fund of Shengjing Hospital, No. 201704; the Support Program for Youth Backbone of China Medical University, No. QGZD2018062.
Informed consent statement: Informed consent to publish was obtained from the patient.
Conflict-of-interest statement: The authors declare no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2013), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Qing Yang, MD, PhD, Professor, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. yangqing_sj@126.com
Telephone: +86-24-23892617
Received: June 1, 2019 Peer-review started: June 4, 2019 First decision: August 1, 2019 Revised: September 5, 2019 Accepted: September 11, 2019 Article in press: September 11, 2019 Published online: October 26, 2019 Processing time: 147 Days and 20.7 Hours
Abstract
BACKGROUND
The diagnosis of multiple primary malignancies (MPMs) has increased due to the improvements and development of diagnostic techniques, in conjunction with extended life span. Notably however, reports of synchronous quadruple primary malignancies remain extremely rare.
CASE SUMMARY
Herein we describe the case of a 56-year-old woman who was diagnosed with synchronous quadruple multiple primary cancers, namely an endocervical adenocarcinoma admixed with neuroendocrine features, localized endometrial endometrioid adenocarcinoma, unilateral endometrioid ovarian carcinoma, and gastric adenocarcinoma. All four of these tumors were removed in one combined surgical procedure.
CONCLUSION
To our knowledge the above-described combination of multiple synchronous primary malignancies has not been previously reported. The nature of the association between them is unknown. Further research should focus on the etiology and mechanisms involved in MPMs.
Core tip: Multiple primary malignancies (MPMs) are rare and most involve two sites. Herein we report an exceptional case of quadruple primary malignancies in a single patient, including endocervical adenocarcinoma, endometrial endometrioid adenocarcinoma, endometrioid ovarian carcinoma, and gastric adenocarcinoma. The nature of MPMs remains unknown, and further research into the etiology and mechanisms of MPMs is warranted.
