Ju UC, Kang WD, Kim SM. Development of immature ovarian teratoma after mature teratoma in a girl with familial ovarian teratoma: A case report. World J Clin Cases 2024; 12(8): 1442-1447 [PMID: 38576805 DOI: 10.12998/wjcc.v12.i8.1442]
Corresponding Author of This Article
Seok Mo Kim, MD, PhD, Professor, Department of Obstetrics and Gynecology, Chonnam National University Medical School, 8 Hakdong, Dong-gu, Gwangju 61469, South Korea. ddiamo94@gmail.com
Research Domain of This Article
Obstetrics & Gynecology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Mar 16, 2024; 12(8): 1442-1447 Published online Mar 16, 2024. doi: 10.12998/wjcc.v12.i8.1442
Development of immature ovarian teratoma after mature teratoma in a girl with familial ovarian teratoma: A case report
U Chul Ju, Woo Dae Kang, Seok Mo Kim
U Chul Ju, Woo Dae Kang, Seok Mo Kim, Department of Obstetrics and Gynecology, Chonnam National University Medical School, Gwangju 61469, South Korea
Co-first authors: U Chul Ju and Woo Dae Kang.
Author contributions: Ju UC, Kang WD and Kim SM designed the research study; Ju UC and Kang WD performed the research and analyzed the data; Kim SM provided help and advice on the data analyzation; Ju UC and Kang WD wrote the manuscript; All authors contributed to editorial changes in the manuscript; All authors read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient and her parents for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read CARE Checklist (2016), and the manuscript was prepared and revised according to CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Seok Mo Kim, MD, PhD, Professor, Department of Obstetrics and Gynecology, Chonnam National University Medical School, 8 Hakdong, Dong-gu, Gwangju 61469, South Korea. ddiamo94@gmail.com
Received: November 13, 2023 Peer-review started: November 13, 2023 First decision: January 9, 2024 Revised: January 15, 2024 Accepted: February 18, 2024 Article in press: February 18, 2024 Published online: March 16, 2024 Processing time: 119 Days and 21.7 Hours
Abstract
BACKGROUND
Immature ovarian teratoma is a rare and aggressive neoplasm that affects young women. This report is the first to describe the development of immature teratoma after ovarian cystectomy for mature teratoma of the ovary in an adolescent female with a family history of ovarian teratoma.
CASE SUMMARY
A 16-year-old girl who had undergone bilateral ovarian cystectomy for mature teratomas 3 years ago showed bilateral adnexal tumors during her regular ultrasonography follow-up every 6 months. She received laparoscopic bilateral ovarian cystectomy, and final histopathology showed grade-1 immature teratoma of the left ovary and mature teratoma of the right ovary. Laparoscopic left salpingo-oophorectomy and staging procedures were performed again. Her mother, maternal aunt, and maternal grandmother had also received surgeries for mature ovarian teratomas.
CONCLUSION
It is important to have guidance on management of patient and family members with familial ovarian teratomas.
Core Tip: This report describes a unique case of an adolescent woman with familial ovarian teratoma that was initially diagnosed as mature ovarian teratoma and later recurred and identified as immature ovarian teratoma during follow-up. Our case highlights the importance of genetic counseling, screening, and close surveillance in families with a predisposition to ovarian teratomas. Collaborative efforts between oncologists, geneticists, and researchers are necessary to determine the underlying mechanisms and develop targeted interventions for individuals at high risk of immature teratomas.
