Al-Haggar MS, Abdelmoneim ZA. Tricuspid mass-curious case of Li-Fraumeni syndrome: A letter to the editor. World J Clin Cases 2024; 12(33): 6644-6646 [PMID: 39600484 DOI: 10.12998/wjcc.v12.i33.6644]
Corresponding Author of This Article
Zahraa A Abdelmoneim, MD, Lecturer, Department of Pediatrics, Genetic Unit, Mansoura University Children Hospital, EL Gomhoria Street, Mansoura 35516, Egypt. hzahraa211@gmail.com
Research Domain of This Article
Genetics & Heredity
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Nov 26, 2024; 12(33): 6644-6646 Published online Nov 26, 2024. doi: 10.12998/wjcc.v12.i33.6644
Tricuspid mass-curious case of Li-Fraumeni syndrome: A letter to the editor
Mohammad S Al-Haggar, Zahraa A Abdelmoneim
Mohammad S Al-Haggar, Department of Pediatrics and Genetics, Mansoura University Children's Hospital, Mansoura 35516, Egypt
Zahraa A Abdelmoneim, Department of Pediatrics, Genetic Unit, Mansoura University Children Hospital, Mansoura 35516, Egypt
Author contributions: Al-Haggar MS revised the manuscript; Abdelmoneim ZA wrote the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zahraa A Abdelmoneim, MD, Lecturer, Department of Pediatrics, Genetic Unit, Mansoura University Children Hospital, EL Gomhoria Street, Mansoura 35516, Egypt. hzahraa211@gmail.com
Received: March 6, 2024 Revised: August 3, 2024 Accepted: September 19, 2024 Published online: November 26, 2024 Processing time: 205 Days and 0.5 Hours
Abstract
We focus specifically on the rare occurrence of cardiac thrombi in Li-Fraumeni syndrome (LFS). LFS is a hereditary risk to a diverse range of specific, uncommon, malignancies. Children and young adults have a heightened susceptibility to many malignancies, particularly soft-tissue and bone tumors, breast malignancies, central nervous system malignancies, adrenocortical carcinoma, and blood cancers. Additionally, LFS patients may experience other cancer types such as gastrointestinal, lung, kidney, thyroid, and skin cancers, along with those affecting gonadal organs (ovaries, testicles, and prostate). An accurate diagnosis of LFS is crucial to enable affected families to access appropriate genetic counseling and undergo surveillance for early cancer detection.
Core Tip: Li-Fraumeni syndrome (LFS) is an inherited propensity to various distinct, frequently uncommon malignancies. Pediatric and adolescent age groups are more likely to acquire many malignancies, including soft-tissue and bone tumors, breast cancer, central nervous system cancers, adrenocortical carcinoma, and blood cancers. LFS individuals may also develop various types of cancer, including gastrointestinal, lung, kidney, thyroid, and skin cancers, as well as those affecting the gonadal organs. An accurate diagnosis of LFS is critical for afflicted families to receive appropriate genetic counseling and be monitored for early cancer detection.
