Published online Jul 26, 2024. doi: 10.12998/wjcc.v12.i21.4536
Revised: May 9, 2024
Accepted: June 13, 2024
Published online: July 26, 2024
Processing time: 100 Days and 16.1 Hours
Intrapancreatic fat deposition (IPFD) exerts a significant negative impact on patients with type 2 diabetes mellitus (T2DM), accelerates disease deterioration, and may lead to impaired β-cell quality and function.
To investigate the correlation between T2DM remission and IPFD.
We enrolled 80 abdominally obese patients with T2DM admitted to our institution from January 2019 to October 2023, including 40 patients with weight loss-induced T2DM remission (research group) and 40 patients with short-term intensive insulin therapy-induced T2DM remission (control group). We comparatively analyzed improvements in IPFD [differential computed tomography (CT) values of the spleen and pancreas and average CT value of the pancreas]; levels of fasting blood glucose (FBG), 2-h postprandial blood glucose (2hPBG), and insulin; and homeostasis model assessment of insulin resistance (HOMA-IR) scores. Correlation analysis was performed to explore the association between T2DM remission and IPFD.
After treatment, the differential CT values of the spleen and pancreas, FBG, 2hPBG, and HOMA-IR in the research group were significantly lower than those before treatment and in the control group, and the average CT value of the pancreas and insulin levels were significantly higher. Correlation analysis revealed that the greater the T2DM remission, the lower the amount of IPFD.
T2DM remission and IPFD are inversely correlated.
Core Tip: This study on 80 patients with type 2 diabetes mellitus (T2DM) with abdominal obesity confirmed that T2DM remission and intrapancreatic fat deposition were negatively correlated, as well as the benefits of liraglutide in glycemic control and pancreatic function repair in T2DM. Our findings are of great significance for advancing research on diabetes mellitus and fat and building appropriate treatment models for patients with T2DM. However, there are limitations such as insufficient sample size and lack of basic experiments.