Liu J, Luo Y, Zhu YR, Wu ZT, Hou Y, Xu YJ, Li L, Ma CW. Correlation between type 2 diabetes mellitus remission and intrapancreatic fat deposition. World J Clin Cases 2024; 12(21): 4536-4542 [PMID: 39070807 DOI: 10.12998/wjcc.v12.i21.4536]
Corresponding Author of This Article
Cun-Wen Ma, MM, Chief Physician, Department of Radiological Medicine, Wenshan Hospital Affiliated to Kunming University of Science and Technology, No. 228 Kaihua East Road, Wenshan 663000, Yunnan Province, China. mcw20241201@163.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jul 26, 2024; 12(21): 4536-4542 Published online Jul 26, 2024. doi: 10.12998/wjcc.v12.i21.4536
Correlation between type 2 diabetes mellitus remission and intrapancreatic fat deposition
Jiang Liu, Yue Luo, Yin-Rong Zhu, Zu-Tao Wu, Yan Hou, Yu-Jie Xu, Li Li, Cun-Wen Ma
Jiang Liu, Yin-Rong Zhu, Zu-Tao Wu, Yan Hou, Yu-Jie Xu, Li Li, Division of Endocrinology, Wenshan Hospital Affiliated to Kunming University of Science and Technology, Wenshan 663000, Yunnan Province, China
Yue Luo, Cun-Wen Ma, Department of Radiological Medicine, Wenshan Hospital Affiliated to Kunming University of Science and Technology, Wenshan 663000, Yunnan Province, China
Author contributions: Liu J and Ma CW contributed to conception, design, data analysis, and manuscript drafting and editing; Liu J, Luo Y, Zhu YR, Wu ZT, Hou Y and Ma CW contributed to collection, assembly of data and revised the manuscript; Liu J, Xu YJ and Li L contributed to conception, resources, and manuscript review and editing; all authors have read and approved the final manuscript.
Supported byKunming University of Science and Technology Joint School Medicine Project, No. KUST-WS2022002Z.
Institutional review board statement: This study was approved by the Ethic Committee of Wenshan Hospital, Kunming University of Science and Technology (Approval No. WYLS2022005).
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: Dr. Ma has nothing to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Cun-Wen Ma, MM, Chief Physician, Department of Radiological Medicine, Wenshan Hospital Affiliated to Kunming University of Science and Technology, No. 228 Kaihua East Road, Wenshan 663000, Yunnan Province, China. mcw20241201@163.com
Received: March 21, 2024 Revised: May 9, 2024 Accepted: June 13, 2024 Published online: July 26, 2024 Processing time: 102 Days and 0.1 Hours
Abstract
BACKGROUND
Intrapancreatic fat deposition (IPFD) exerts a significant negative impact on patients with type 2 diabetes mellitus (T2DM), accelerates disease deterioration, and may lead to impaired β-cell quality and function.
AIM
To investigate the correlation between T2DM remission and IPFD.
METHODS
We enrolled 80 abdominally obese patients with T2DM admitted to our institution from January 2019 to October 2023, including 40 patients with weight loss-induced T2DM remission (research group) and 40 patients with short-term intensive insulin therapy-induced T2DM remission (control group). We comparatively analyzed improvements in IPFD [differential computed tomography (CT) values of the spleen and pancreas and average CT value of the pancreas]; levels of fasting blood glucose (FBG), 2-h postprandial blood glucose (2hPBG), and insulin; and homeostasis model assessment of insulin resistance (HOMA-IR) scores. Correlation analysis was performed to explore the association between T2DM remission and IPFD.
RESULTS
After treatment, the differential CT values of the spleen and pancreas, FBG, 2hPBG, and HOMA-IR in the research group were significantly lower than those before treatment and in the control group, and the average CT value of the pancreas and insulin levels were significantly higher. Correlation analysis revealed that the greater the T2DM remission, the lower the amount of IPFD.
Core Tip: This study on 80 patients with type 2 diabetes mellitus (T2DM) with abdominal obesity confirmed that T2DM remission and intrapancreatic fat deposition were negatively correlated, as well as the benefits of liraglutide in glycemic control and pancreatic function repair in T2DM. Our findings are of great significance for advancing research on diabetes mellitus and fat and building appropriate treatment models for patients with T2DM. However, there are limitations such as insufficient sample size and lack of basic experiments.
