Ha Y, Kim JH, Kim J, Kwon H. Non-surgical treatment of diabetic foot ulcers on the dorsum of the foot with polydeoxyribonucleotide injection: Two case reports. World J Clin Cases 2024; 12(20): 4446-4451 [DOI: 10.12998/wjcc.v12.i20.4446]
Corresponding Author of This Article
Hyeokjae Kwon, MD, PhD, Assistant Professor, Surgeon, Department of Plastic and Reconstructive Surgery, Chungnam National University Hospital, 282 Munhwa-ro Jung-gu Daejeon, Daejeon 35015, South Korea. kwon.hyeokjae@cnuh.co.kr
Research Domain of This Article
Surgery
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jul 16, 2024; 12(20): 4446-4451 Published online Jul 16, 2024. doi: 10.12998/wjcc.v12.i20.4446
Non-surgical treatment of diabetic foot ulcers on the dorsum of the foot with polydeoxyribonucleotide injection: Two case reports
Yooseok Ha, Jeong-Hee Kim, Jiyoung Kim, Hyeokjae Kwon
Yooseok Ha, Jeong-Hee Kim, Hyeokjae Kwon, Department of Plastic and Reconstructive Surgery, Chungnam National University Hospital, Daejeon 35015, South Korea
Jiyoung Kim, College of Nursing, Woosuk University, Wanju-gun 55338, South Korea
Author contributions: Kwon H performed the research; Ha Y and Kim JH wrote the manuscript (original draft); Kim J and Kwon H wrote the manuscript (reviewing and editing); All authors have read and approved the final manuscript.
Informed consent statement: Informed consent was obtained from all patients for being included in the study.
Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hyeokjae Kwon, MD, PhD, Assistant Professor, Surgeon, Department of Plastic and Reconstructive Surgery, Chungnam National University Hospital, 282 Munhwa-ro Jung-gu Daejeon, Daejeon 35015, South Korea. kwon.hyeokjae@cnuh.co.kr
Received: April 10, 2024 Revised: May 15, 2024 Accepted: May 29, 2024 Published online: July 16, 2024 Processing time: 80 Days and 13.1 Hours
Abstract
BACKGROUND
Diabetic foot ulcers are caused by a variety of factors, including peripheral neuropathy, peripheral arterial disease, impaired wound healing mechanisms, and repetitive trauma. Patients with diabetic foot ulcer on the dorsum of the foot are often treated surgically. However, the right non-surgical therapy must be chosen if surgical choices are contraindicated or if the patient prefers conservative treatment over surgery.
CASE SUMMARY
The purpose of this case report is to highlight the efficacy of polydeoxyribonucleotide (PDRN) injection as a non-surgical treatment option for diabetic foot ulcers on the dorsum of the foot, particularly in patients who choose against surgical intervention. This case report presents two cases of diabetic foot ulcers located on the dorsum of the foot that were successfully treated with PDRN injection as a non-surgical intervention.
CONCLUSION
If the patient declines surgery for diabetic ulcers with Wagner grade II or below, PDRN injection can be effective if necrotic tissue is removed and the wound bed kept clean.
Core Tip: If a diabetic foot wound of Wager grade II or less is located on the dorsum of the foot and is not amenable to surgical treatment, polydeoxyribonucleotide injection combined with a minimally invasive treatment of debridement under local anesthesia may help wound healing in patients who are not amenable to surgical treatment.
