Xu JJ, Dai J, Xie QH, Du PC, Li C, Zhou H. Effect of Luhong formula on the cardiac rehabilitation of patients with chronic heart failure. World J Clin Cases 2024; 12(17): 3027-3034 [PMID: 38898832 DOI: 10.12998/wjcc.v12.i17.3027]
Corresponding Author of This Article
Ji-Jie Xu, PhD, Doctor, Department of Cardiology & Cardiovascular Research Institute, Shanghai Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine, No. 181 Youyi Road, Baoshan District, Shanghai 201999, China. adamxu628@163.com
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jun 16, 2024; 12(17): 3027-3034 Published online Jun 16, 2024. doi: 10.12998/wjcc.v12.i17.3027
Effect of Luhong formula on the cardiac rehabilitation of patients with chronic heart failure
Ji-Jie Xu, Jian Dai, Qi-Hai Xie, Pei-Chao Du, Cha Li, Hua Zhou
Ji-Jie Xu, Jian Dai, Qi-Hai Xie, Pei-Chao Du, Cha Li, Hua Zhou, Department of Cardiology & Cardiovascular Research Institute, Shanghai Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai 201999, China
Author contributions: Xu JJ proposed the concept of this study; Xu JJ, Dai J, Xie QH and Zhou H contributed to data collection; Xu JJ drafted the first draft; Xu JJ, Dai J and Zhou H contributed to the formal analysis of this study; Du PC and Li C conducted guidance research, methodology, and visualization; all authors participated in the study, validated the study, and jointly reviewed and edited the manuscript.
Supported byScience and Technology Commission of Shanghai Municipality, No. 21Y11920100; National Natural Science Foundation of China, No. 81904016; Baoshan District Health Commission, No. BSZK-2023-Z02.
Institutional review board statement: This study was approved by the Ethic Committee of Shanghai Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine (Approval No. 202119).
Informed consent statement: All the study subjects provided informed consent.
Conflict-of-interest statement: Dr. Xu has nothing to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ji-Jie Xu, PhD, Doctor, Department of Cardiology & Cardiovascular Research Institute, Shanghai Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine, No. 181 Youyi Road, Baoshan District, Shanghai 201999, China. adamxu628@163.com
Received: March 1, 2024 Revised: April 22, 2024 Accepted: April 24, 2024 Published online: June 16, 2024 Processing time: 95 Days and 8.3 Hours
Abstract
BACKGROUND
Current treatments for chronic heart failure (CHF) are therapeutically ineffective. The optimization of treatments for this disease needs to be explored and analyzed.
AIM
To analyze the effect of using Luhong Formula in the cardiac rehabilitation of patients with CHF and its influence on cardiopulmonary function (CPF) and prognosis.
METHODS
In total, 160 patients with CHF admitted between June 2022 and June 2023 were selected, including 75 receiving perindopril (control group) and 85 receiving Luhong Formula (research group). We conducted comparative analyses on the curative effects of traditional Chinese medicine (TCM) syndromes and cardiac function, CPF [oxygen consumption at the anaerobic threshold (VO2 AT) and at peak exercise (peak VO2)], echocardiographic indexes [left atrial volume index (LAVI), left ventricular muscle mass index (LVMI), left ventricular ejection fraction (LVEF)], and prognosis [major adverse cardiovascular events (MACEs) at 6 months follow-up].
RESULTS
The research group showed markedly higher curative effects of TCM syndromes and cardiac function than the control group. In addition, post-treatment VO2 AT, peak VO2, LVMI and LVEF in the research group were significantly higher, whereas LAVI was significantly lower, than those of the control group. Furthermore, fewer patients in the research group developed MACEs at the 6-month follow-up.
CONCLUSION
Luhong Formula is more therapeutically effective than perindopril for the cardiac rehabilitation of patients with CHF, specifically in enhancing CPF and prognosis.
Core Tip: Traditional Chinese medicine (TCM) has great potential and clinical value in the treatment of chronic heart failure (CHF). This study analyzed the clinical efficacy of Luhong formula in the treatment of patients with CHF in terms of its curative effects on TCM syndromes and cardiac function, cardiopulmonary function (CPF), echocardiographic indexes, and prognosis. Luhong Formula showed a significantly better therapeutic effect on cardiac rehabilitation for CHF than perindopril, specifically in improving CPF and prognosis. The findings demonstrate the potential of Luhong formula as an effective TCM-based treatment option that can be integrated into cardiac rehabilitation strategies for CHF.
