Observational Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 16, 2023; 11(5): 1049-1057
Published online Feb 16, 2023. doi: 10.12998/wjcc.v11.i5.1049
Right hemicolectomy combined with duodenum-jejunum Roux-en-Y anastomosis for hepatic colon carcinoma invading the duodenum: A single-center case series
Pei-Gen Liu, Pan-Feng Feng, Xiang-Fan Chen
Pei-Gen Liu, Department of General Surgery, Central Hospital of Panzhihua City, Panzhihua 617000, Sichuan Province, China
Pan-Feng Feng, Xiang-Fan Chen, Department of Pharmacy, Affiliated Hospital 2 of Nantong University, Nantong 226001, Jiangsu Province, China
Author contributions: Liu PG and Feng PF contributed to the work equally; All authors made a significant contribution to the work reported, whether in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas, took part in drafting, revising or critically reviewing the article, gave final approval of the version to be published, have agreed on the journal to which the article has been submitted, and agree to be accountable for all aspects of the work.
Institutional review board statement: This study was approved by the Ethics Committee of Panzhihua Central Hospital (No. 20160001).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiang-Fan Chen, Doctor, Research Scientist, Researcher, Department of Pharmacy, Affiliated Hospital 2 of Nantong University, No. 6 Haierxiang North Road, Nantong 226001, Jiangsu Province, China. cxf8448180@163.com
Received: November 26, 2022
Peer-review started: November 26, 2022
First decision: December 26, 2022
Revised: January 6, 2023
Accepted: January 19, 2023
Article in press: January 19, 2023
Published online: February 16, 2023
Processing time: 79 Days and 23.2 Hours
Abstract
BACKGROUND

Hepatic colon carcinoma invading the duodenum is not common in clinical practice. Surgical treatment of colonic hepatic cancer that invades the duodenum is difficult, and the surgical risk is high.

AIM

To discuss the efficacy and safety of duodenum-jejunum Roux-en-Y anastomosis for the treatment of hepatic colon carcinoma invading the duodenum.

METHODS

From 2016 to 2020, 11 patients from Panzhihua Central Hospital diagnosed with hepatic colon carcinoma were enrolled in this study. Clinical and therapeutic effects and prognostic indicators were retrospectively analyzed to determine the efficacy and safety of our surgical procedures. All patients underwent radical resection of right colon cancer combined with duodenum-jejunum Roux-en-Y anastomosis.

RESULTS

The median tumor size was 65 mm (r50-90). Major complications (Clavien-DindoI-II) occurred in 3 patients (27.3%); the average length of hospital stay was 18.09 ± 4.21 d; and only 1 patient (9.1%) was readmitted during the 1st mo after the surgery. The 30-d mortality rate was 0%. After a median follow-up of 41 m (r7-58), the disease-free survival at 1, 2, and 3 years was 90.9%, 90.9% and 75.8%, respectively; the overall survival at 1, 2, and 3 years was 90.9%.

CONCLUSION

In selected patients, radical resection of right colon cancer combined with duodenum-jejunum Roux-en-Y anastomosis is clinically effective, and the complications are manageable. The surgical procedure also has an acceptable morbidity rate and mid-term survival.

Keywords: Colonic liver cancer; Duodenum; Tumor infiltration; Duodenum-jejunum Roux-en-Y anastomosis; Case study

Core Tip: In summary, radical right hemicolectomy and duodenum-jejunum Roux-en-Y anastomosis are feasible and safe in selected patients with colorectal carcinoma complicated with duodenal invasion, with a low incidence of postoperative complications and a good prognosis for tumor treatment. We still need larger prospective studies with longer follow-up to confirm these preliminary findings.