Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 6, 2023; 11(31): 7543-7552
Published online Nov 6, 2023. doi: 10.12998/wjcc.v11.i31.7543
Analysis of risk factors for postoperative deep vein thrombosis after craniotomy and nomogram model construction
Zhen-Jin Su, Hong-Rui Wang, Li-Qin Liu, Nan Li, Xin-Yu Hong
Zhen-Jin Su, Xin-Yu Hong, Department of Neurosurgery, The First Hospital of Jilin University, Changchun 130000, Jilin Province, China
Hong-Rui Wang, Li-Qin Liu, Nan Li, Department of Operating Theater, The First Hospital of Jilin University, Changchun 130000, Jilin Province, China
Author contributions: Su ZJ, Wang HR, Liu LQ, Li N, Hong XY contributed equally to this work; Su ZJ, Liu LQ participated in data collection; Wang HY, Li N processed and analyzed the data; Su ZJ double-checked the results of the data analyses and wrote the first draft; Hong XY reviewed and revised the manuscript and confirmed the final version.
Institutional review board statement: This retrospective study has been reviewed by the Ethics Committee of the First Hospital of Jilin University, and all procedures being performed were part of routine care.
Informed consent statement: Informed written consent was obtained from the patients for the release of clinical data involved in this study.
Conflict-of-interest statement: The authors declare that the research was conducted without any commercial or financial relationships that could be construed as a potential conflict of interest.
Data sharing statement: The authors state that raw data related to the study will be shared.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xin-Yu Hong, PhD, Professor, Department of Neurosurgery, The First Hospital of Jilin University, No. 71 Xinmin Street, Changchun 130000, Jilin Province, China. hongxy@jlu.edu.cn
Received: August 14, 2023
Peer-review started: August 14, 2023
First decision: September 26, 2023
Revised: October 5, 2023
Accepted: October 23, 2023
Article in press: October 23, 2023
Published online: November 6, 2023
Abstract
BACKGROUND

Deep vein thrombosis (DVT) of the lower extremity is one of the most common postoperative complications, especially after craniocerebral surgery. DVT may lead to pulmonary embolism, which has a devastating impact on patient prognosis. This study aimed to investigate the incidence and risk factors of DVT in the lower limbs following craniocerebral surgery.

AIM

To identify independent risk factors for the development of postoperative DVT and to develop an effective risk prediction model.

METHODS

The demographic and clinical data of 283 patients who underwent craniocerebral surgery between December 2021 and December 2022 were retrospectively analyzed. The independent risk factors for lower extremity DVT were identified by univariate and multivariate analyses. A nomogram was created to predict the likelihood of lower extremity DVT in patients who had undergone craniocerebral surgery. The efficacy of the prediction model was determined by receiver operating characteristic curve using the probability of lower extremity DVT for each sample.

RESULTS

Among all patients included in the analysis, 47.7% developed lower extremity DVT following craniocerebral surgery. The risk of postoperative DVT was higher in those with a longer operative time, and patients with intraoperative intermittent pneumatic compression were less likely to develop postoperative DVT.

CONCLUSION

The incidence of lower extremity DVT following craniocerebral surgery is significant, highlighting the importance of identifying independent risk factors. Interventions such as the use of intermittent pneumatic compression during surgery may prevent the formation of postoperative DVT.

Keywords: Deep vein thrombosis, Craniotomy surgery, Risk factors, Nomogram

Core Tip: Deep vein thrombosis (DVT) of the lower extremity is one of the most common postoperative complications, especially after craniocerebral surgery. DVT may lead to pulmonary embolism, which has a devastating impact on patient prognosis. Therefore, preventing the formation of lower limb Deep vein thrombosis is crucial after surgery. This study aimed to investigate the incidence and risk factors of DVT in the lower limbs following craniocerebral surgery and develop effective risk prediction models.