Published online Sep 16, 2023. doi: 10.12998/wjcc.v11.i26.6066
Peer-review started: April 24, 2023
First decision: May 8, 2023
Revised: May 20, 2023
Accepted: August 3, 2023
Article in press: August 3, 2023
Published online: September 16, 2023
Chronic heart failure (CHF) is a serious and prevalent condition characterized by impaired cardiac function and inflammation. Standard therapy for CHF has limitations, prompting the exploration of alternative treatments. Recombinant human brain natriuretic peptide (BNP) has emerged as a potential therapy, with evidence suggesting that it can improve cardiac function and reduce inflammation in patients with CHF. However, further research is required to determine the efficacy and safety of lyophilized recombinant human BNP in CHF patients and its impact on microinflammatory status. This study aimed to investigate the effects of lyophilized recombinant human BNP therapy on CHF patients’ cardiac function and microinflammatory status.
To investigate the effects of freeze-dried recombinant human BNP therapy on cardiac function and microinflammatory status in patients with CHF.
In total, 102 CHF patients admitted to our hospital from January 2021 to January 2022 were randomly assigned to control and observation groups (n = 51 pa
The overall clinical efficacy was higher in the observation group than in the control group. Compared with baseline, serum hypersensitive C-reactive protein, N-terminal proBNP, and troponin I level, and physical, emotional, social, and economic scores were lower in both groups after treatment, with greater re
Freeze-dried recombinant human BNP therapy can improve heart function and enhance microinflammatory status, thereby improving overall quality of life without any obvious side effects. This therapy is safe and reliable.
Core Tip: Lyophilized recombinant human brain natriuretic peptide therapy can improve heart function and reduce microinflammation in patients with chronic heart failure, which signifies its potential as a safe and effective treatment option.