Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 6, 2023; 11(13): 3086-3091
Published online May 6, 2023. doi: 10.12998/wjcc.v11.i13.3086
Solitary acral persistent papular mucinosis nodule: A case report and summary of eight Korean cases
Yu Jeong Park, Hui Young Shin, Woo Kyoung Choi, Ai-Young Lee, Seung Ho Lee, Jong Soo Hong
Yu Jeong Park, Hui Young Shin, Woo Kyoung Choi, Ai-Young Lee, Seung Ho Lee, Jong Soo Hong, Department of Dermatology, Dongguk University Ilsan Hospital, College of Medicine, Dongguk University, Goyang-si, Gyeonggi-do, Korea 10326, South Korea
Author contributions: Park YJ and Hong JS wrote the first draft of the manuscript, and all authors reviewed and edited the manuscript and approved the final version of the manuscript.
Informed consent statement: The primary version of the consent that has been signed by the patient in the study is attached as a separate file.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jong Soo Hong, MD, PhD, Professor, Department of Dermatology, Dongguk University Ilsan Hospital, College of Medicine, Dongguk University, Dongguk University Ilsan Medical Center, 27, Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, Korea 10326, South Korea. jsttjstt@hanmail.net
Received: December 29, 2022
Peer-review started: December 29, 2022
First decision: March 10, 2023
Revised: March 22, 2023
Accepted: March 31, 2023
Article in press: March 31, 2023
Published online: May 6, 2023
Processing time: 117 Days and 5.8 Hours
Abstract
BACKGROUND

Acral persistent papular mucinosis (APPM) is a rare idiopathic subtype of localized lichen myxedematosus. To date, there have been 40 APPM cases reported worldwide; however, only 7 cases have been reported in the Korean literature.

CASE SUMMARY

A 70-year-old man was referred to our hospital with a solitary pinkish nodule on the dorsum of his right hand. Despite the absence of symptoms, the patient wanted to know the exact diagnosis; thus, a biopsy was performed. Histopathological examination of a biopsy specimen obtained from the nodule on the dorsum of his hand revealed orthokeratotic hyperkeratosis with patchy parakeratosis, prominent hypergranulosis, and diffuse dissecting mucinous deposition between collagen bundles, along with some bland-looking spindle cells throughout the dermis. The nodule was histologically diagnosed as an APPM, and an intralesional triamcinolone injection (2.5 mg/mL) was started every 2 wk. After three sessions of treatment, the patient showed marked improvements.

CONCLUSION

To the best of our knowledge, this is the first case of a Korean APPM presenting as a solitary nodule that showed a marked response to triamcinolone intralesional injection. Since it is a rare disease, we report this case to contribute to future research on the pathogenesis and treatment of APPM.

Keywords: Acral persistent papular mucinosis; Localized lichen myxedematosus; Cutaneous mucinosis; Mucin; Case report

Core Tip: Acral persistent papular mucinosis (APPM) is a rare idiopathic subtype of localized lichen myxedematosus. To date, 40 cases have been reported worldwide; however, only seven cases have been reported in the Korean literature. This article reports on a rare case of solitary APPM, which was histologically diagnosed in a 70-year-old Korean man with a pinkish nodule on the dorsum of his hand. The patient showed marked improvement after three sessions of intralesional triamcinolone injection. This is the first reported case of a Korean APPM presenting as a solitary nodule and emphasizes the importance of continued research into the pathogenesis and treatment of this rare disease.