Huang WY, Zhang YQ, Yang XH. Neurothekeoma located in the hallux and axilla: Two case reports. World J Clin Cases 2022; 10(5): 1738-1746 [PMID: 35211617 DOI: 10.12998/wjcc.v10.i5.1738]
Corresponding Author of This Article
Xiang-Hong Yang, PhD, Professor, Department of Pathology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. yangxh@sj-hospital.org
Research Domain of This Article
Pathology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Feb 16, 2022; 10(5): 1738-1746 Published online Feb 16, 2022. doi: 10.12998/wjcc.v10.i5.1738
Neurothekeoma located in the hallux and axilla: Two case reports
Wan-Ying Huang, Yi-Qi Zhang, Xiang-Hong Yang
Wan-Ying Huang, Xiang-Hong Yang, Department of Pathology, Shengjing Hospital of China Medical University, Shenyang 110000, Liaoning Province, China
Yi-Qi Zhang, Department of Orthopedics, Shengjing Hospital, China Medical University, Shenyang 110000, Liaoning Province, China
Author contributions: Huang WY and Yang XH designed the study; Huang WY analysed the pathology images and wrote the manuscript; Zhang YQ helped prepare the clinical information; all authors read and approved the final manuscript.
Supported bythe National Natural Science Foundation of China, No. 81773108.
Informed consent statement: Written informed consent was obtained from the patients for the publication of this case report and accompanying images.
Conflict-of-interest statement: The authors have no conflicts of interest to report.
CARE Checklist (2016) statement: We have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution noncommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiang-Hong Yang, PhD, Professor, Department of Pathology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. yangxh@sj-hospital.org
Received: October 16, 2021 Peer-review started: October 16, 2021 First decision: November 17, 2021 Revised: November 29, 2021 Accepted: December 31, 2021 Article in press: December 31, 2021 Published online: February 16, 2022 Processing time: 118 Days and 2.2 Hours
Abstract
BACKGROUND
Neurothekeomas (NTKs) are rare benign soft tissue tumours that typically occur in the head, trunk, and upper limbs and are rare in other parts of the body.
CASE SUMMARY
Herein, we present two rare cases in which primary NTKs were located in the hallux and axilla. A 47-year-old woman complained of a verrucous bulge on the plantar side of the left hallux. The surface skin of the tumour was abraded due to poor wound healing. A 6-year-old boy complained of a gradually growing subcutaneous mass in the axilla. The tumours of both patients were completely resected, and the diagnosis of NTK was confirmed by histopathology. At the one-year follow-up, both patients had a good prognosis without local recurrence.
CONCLUSION
To date, NTKs located in the hallux and axilla have rarely been reported in the literature. We describe NTKs that occurred in unconventional areas and summarize the challenges in their diagnosis and differential diagnosis.
Core Tip: In these patients, the lack of specificity of clinical symptoms and imaging examination findings as well as the unusual location of neurothekeomas increased the difficulty in diagnosis and treatment. Histopathological examination and immunohistochemical staining may help confirm the diagnosis, but there are still many challenges in the identification of similar diseases.
