Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 16, 2022; 10(5): 1623-1629
Published online Feb 16, 2022. doi: 10.12998/wjcc.v10.i5.1623
Primary orbital monophasic synovial sarcoma with calcification: A case report
Ming-Yu Ren, Jing Li, Rui-Miao Li, Yi-Xiang Wu, Rui-Juan Han, Chi Zhang
Ming-Yu Ren, Rui-Miao Li, Yi-Xiang Wu, Rui-Juan Han, Chi Zhang, Department of Orbital Disease and Ocular Tumor, Hebei Eye Hospital, Xingtai 054001, Hebei Province, China
Jing Li, Intensive Care Unit, Xingtai Third Hospital, Xingtai 054001, Hebei Province, China
Author contributions: Ren MY conceptualized this study, made the literature review and wrote the first draft of this paper; Li J, Li RM, Wu YX, Han RJ, and Zhang C made the literature review; all authors revised the paper and approved the final version for submission.
Supported by the Science and Technology Planning Project of Xingtai, No.2019ZC246.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ming-Yu Ren, MMed, Associate Chief Physician, Department of Orbital Disease and Ocular Tumor, Hebei Eye Hospital, No. 399 Quanbeidong, Xingtai 054001, Hebei Province, China. 147237583@qq.com
Received: July 31, 2021
Peer-review started: July 31, 2021
First decision: October 25, 2021
Revised: October 28, 2021
Accepted: December 28, 2021
Article in press: December 28, 2021
Published online: February 16, 2022
Processing time: 195 Days and 2.9 Hours
Abstract
BACKGROUND

Synovial sarcoma is a malignant mesenchymal neoplasm with variable epithelial differentiation. Most synovial sarcoma cases are reported in young adults and can arise in any body site. Notably, primary orbital synovial sarcoma is rare.

CASE SUMMARY

An 8-year-old east Asian girl with 1-month history of gradual painless proptosis and lacrimation of the right eye was admitted. The patient presented with painless proptosis, downward eyeball displacement, and upward movement disorders. According to clinical manifestations, imaging examinations and postoperative immunohistochemical examinations, the diagnosis was monophasic synovial sarcoma with calcification. The patient underwent anterior orbitotomy procedure for removal of the right orbital mass under general anesthesia. The diagnosis of monophasic synovial sarcoma with calcification was confirmed finally through histological and immunohistochemical exam. The follow-up period was 6 mo, and no recurrence was observed during this period.

CONCLUSION

Primary orbital monophasic synovial sarcoma with calcification is a rare sarcoma, and clinical manifestations and imaging results are not specific. The tumor may present similar features as a benign tumor. Comprehensive analysis of clinical, radiological, and pathological findings is critically important for making the right diagnosis. Conventional treatment approach for synovial sarcoma is surgical resection with adjuvant or neoadjuvant radiotherapy, which is highly effective for localized tumors.

Keywords: Orbital tumor; Synovial sarcoma; Calcification; Histological; Case report

Core Tip: We describe a patient with 1-month history of gradual painless proptosis and lacrimation of the right eye. The patient underwent anterior orbitotomy procedure for removal of the right orbital mass under general anesthesia. The diagnosis of monophasic synovial sarcoma with calcification was confirmed finally through histological and immunohistochemical exam. The follow-up period was 6 mo, and no recurrence was observed during this period. This case illustrates the tumor may present similar features as a benign tumor. Comprehensive analysis of clinical, radiological, and pathological findings is critically important for making the right diagnosis.