Yu SL, Sun PL, Li J, Jia M, Gao HW. Giant nodular fasciitis originating from the humeral periosteum: A case report. World J Clin Cases 2022; 10(5): 1572-1579 [PMID: 35211594 DOI: 10.12998/wjcc.v10.i5.1572]
Corresponding Author of This Article
Hong-Wen Gao, MD, PhD, Chief Physician, Department of Pathology, The Second Hospital of Jilin University, No. 218 Ziqiang Road, Changchun 130041, Jilin Province, China. gaohongwen@jlu.edu.cn
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Shi-Li Yu, Ping-Li Sun, Jian Li, Meng Jia, Hong-Wen Gao, Department of Pathology, The Second Hospital of Jilin University, Changchun 130041, Jilin Province, China
Author contributions: Sun PL designed the review; Yu SL collected the data and prepared the draft; Li J and Jia M participated in data interpretation; Sun PL and Gao HW provided research fund; all authors read and approved the final manuscript.
Supported byJilin Province Department of Finance Project, No. 2019SCZT005, No. 2019SRCJ007 and No. 2020SCZT007; National Natural Science Foundation of China, No. 81902342; and Health Commission of Jilin Province, No. 2019Q002.
Informed consent statement: Informed written consent was obtained from the patient for publication of this case report.
Conflict-of-interest statement: The authors declare that they have no competing interests to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong-Wen Gao, MD, PhD, Chief Physician, Department of Pathology, The Second Hospital of Jilin University, No. 218 Ziqiang Road, Changchun 130041, Jilin Province, China. gaohongwen@jlu.edu.cn
Received: November 27, 2020 Peer-review started: November 30, 2020 First decision: September 28, 2021 Revised: October 9, 2021 Accepted: January 6, 2022 Article in press: January 6, 2022 Published online: February 16, 2022 Processing time: 441 Days and 4.6 Hours
Abstract
BACKGROUND
Nodular fasciitis (NF) is a self-limiting tumor that mostly occurs in the subcutaneous superficial fascia. NF originating from the appendicular periosteum is extremely rare. A large NF lesion of periosteal origin can be misdiagnosed as a malignant bone tumor and may cause overtreatment.
CASE SUMMARY
A right axillary mass was found in a 46-year-old man and was initially diagnosed intraoperatively as low-grade sarcoma, but later diagnosed as NF after post-resection histopathological evaluation. Furthermore, fluorescence in situ hybridization analysis revealed a USP6 gene rearrangement that confirmed the diagnosis. To the best of our knowledge, this is the first case of NF in the humeral periosteum.
CONCLUSION
NF poses a diagnostic challenge as it is often mistaken for sarcoma. Postoperative histopathological examination of whole sections can be combined with immunohistochemical staining and, if necessary, the diagnosis can be confirmed by molecular detection, and thus help avoid overtreatment.
Core Tip: This article provides a comprehensive overview of the clinicopathological, immunohistochemical, and molecular features of nodular fasciitis originating from the humeral periosteum. To date, this is the first report of nodular fasciitis originating from the humeral periosteum and this type of research is critical to further our understanding of these lesions and advance pathological diagnoses.
