He C, Ge XP, Zhang XH, Chen P, Li BZ. Multiple myeloma presenting with amyloid arthropathy as the first manifestation: Two case reports. World J Clin Cases 2022; 10(35): 13028-13037 [PMID: 36568992 DOI: 10.12998/wjcc.v10.i35.13028]
Corresponding Author of This Article
Bing-Zong Li, PhD, Professor, Department of Haematology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China.lbzwz0907@hotmail.com
Research Domain of This Article
Hematology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Dec 16, 2022; 10(35): 13028-13037 Published online Dec 16, 2022. doi: 10.12998/wjcc.v10.i35.13028
Multiple myeloma presenting with amyloid arthropathy as the first manifestation: Two case reports
Chuan He, Xue-Ping Ge, Xiao-Hui Zhang, Ping Chen, Bing-Zong Li
Chuan He, Xue-Ping Ge, Xiao-Hui Zhang, Ping Chen, Bing-Zong Li, Department of Haematology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China
Author contributions: Li BZ and He C designed the research; Ge XP, Zhang XH, and Chen P performed data extraction; He C and Li BZ wrote the paper.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work, there is no professional or other personal interest of any nature or kind in any product, service and/or company that could be construed as influencing the position presented in, or the review of, the manuscript entitled. We have received research funding from Soochow Science and Technology Development Plan SLT201922.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bing-Zong Li, PhD, Professor, Department of Haematology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China.lbzwz0907@hotmail.com
Received: August 14, 2022 Peer-review started: August 14, 2022 First decision: September 5, 2022 Revised: October 26, 2022 Accepted: November 8, 2022 Article in press: November 8, 2022 Published online: December 16, 2022 Processing time: 115 Days and 19.7 Hours
Abstract
BACKGROUND
Multiple myeloma (MM) can be accompanied by amyloidosis, which occurs in a small number of patients and is characterized by deposition of light chains in the joints, leading to multiple myeloma-associated amyloid arthropathy (MAA). As a rare complication of MM, clinical manifestations of MAA are often similar to those of rheumatoid arthritis, and the two are easily confused.
CASE SUMMARY
In recent years, our center treated two patients of MM with amyloid arthropathy as the first manifestation, both of whom presented with polyarthritis. After treatment for MM, both patients achieved complete remission. However, subsequently, the two patients underwent hip arthroplasty for femoral neck fractures. Congo red staining and immunofluorescence of the joint tissues confirmed MAA after surgery. Eventually, one of the patients died of MM recurrence, while the other survived.
CONCLUSION
MAA should be regarded as an initial symptom of MM and should be taken seriously.
Core Tip: Multiple myeloma-associated amyloid arthropathy is easily confused with other types of arthritis when it appears as the first manifestation of MM. Delayed treatment may affect prognosis. We report two cases of MM presenting with amyloid arthropathy as the first manifestation.
