Lu SN, Huang C, Li LL, Di LJ, Yao J, Tuo BG, Xie R. Synchronous early gastric and intestinal mucosa-associated lymphoid tissue lymphoma in a Helicobacter pylori-negative patient: A case report. World J Clin Cases 2022; 10(33): 12447-12454 [PMID: 36483796 DOI: 10.12998/wjcc.v10.i33.12447]
Corresponding Author of This Article
Rui Xie, PhD, Full Professor, Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, No. 149 Dalian Road, Zunyi 563003, Guizhou Province, China. xr19841029@aliyun.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Nov 26, 2022; 10(33): 12447-12454 Published online Nov 26, 2022. doi: 10.12998/wjcc.v10.i33.12447
Synchronous early gastric and intestinal mucosa-associated lymphoid tissue lymphoma in a Helicobacter pylori-negative patient: A case report
Sheng-Nian Lu, Cheng Huang, Ling-Li Li, Lian-Jun Di, Jin Yao, Bi-Guang Tuo, Rui Xie
Sheng-Nian Lu, Cheng Huang, Ling-Li Li, Lian-Jun Di, Bi-Guang Tuo, Rui Xie, Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, Guizhou Province, China
Jin Yao, Pathology Department, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, Guizhou Province, China
Author contributions: Lu SN wrote the manuscript; Huang C, Di LJ and Li LL diagnosed the patient and contributed to the endoscopic; Yao J contributed to pathological diagnosis and provided the pathological images; Tuo BG and Xie R performed the treatment and revised the manuscript; and all authors have read and approve the final manuscript.
Supported byMaster' s Start-up Fund of the Affiliated Hospital of Zunyi Medical College, No. [2015]34; Basic Research Projects of Science and Technology Department of Guizhou Province, No. Qian Ke He-zk[2022]-646; and Collaborative Innovation Center of Chinese Ministry of Education, No. 2020-39.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rui Xie, PhD, Full Professor, Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, No. 149 Dalian Road, Zunyi 563003, Guizhou Province, China. xr19841029@aliyun.com
Received: September 16, 2022 Peer-review started: September 16, 2022 First decision: September 27, 2022 Revised: October 3, 2022 Accepted: October 31, 2022 Article in press: October 31, 2022 Published online: November 26, 2022 Processing time: 68 Days and 0.1 Hours
Abstract
BACKGROUND
Mucosa-associated lymphoid tissue (MALT) lymphoma occurs largely in the digestive tract, with the stomach being the most commonly affected organ, followed by the small intestine, large intestine, and esophagus. It is rarely found in both the stomach and colon. Helicobacter pylori (H. pylori) infection is strongly associated with gastric MALT lymphoma, although there is a small number of H. pylori-negative gastric MALT lymphomas. Diagnosis of MALT lymphoma is challenging because of nonspecific symptoms and diverse presentations of endoscopic findings.
CASE SUMMARY
We report a case of an asymptomatic patient who during screening endoscopy and was found to have stromal tumor-like submucosal uplift lesions in the stomach body and polypoid lesions in the rectum. After endoscopic resection, the patient was diagnosed with multiple early simultaneous gastrointestinal MALT lymphomas.
CONCLUSION
This study may help improve our understanding of MALT lymphomas and multifocal lesions treated using early endoscopy.
Core Tip: Mucosa-associated lymphoid tissue (MALT) lymphoma is a subtype of non-Hodgkin’s lymphoma that is rarely found in both the stomach and colon. Diagnosis of MALT lymphoma is challenging because of nonspecific symptoms and diverse presentations of endoscopic findings. Helicobacter pylori (H. pylori) infection is the initial event in gastric MALT lymphoma. We report a case of H. pylori-negative gastric MALT lymphoma mimicking a gastric stromal tumor, together with a rectal presentation of intestinal MALT with a polyp-like appearance, which were treated endoscopically with complete remission.
