Liu XH, Zou QM, Cao JD, Wang ZC. Primary squamous cell carcinoma with sarcomatoid differentiation of the kidney associated with ureteral stone obstruction: A case report . World J Clin Cases 2022; 10(32): 11942-11948 [PMID: 36405295 DOI: 10.12998/wjcc.v10.i32.11942]
Corresponding Author of This Article
Zhi-Chao Wang, MD, Attending Doctor, Department of Urology Surgery, Fangcun Hospital of Guangdong Provincial Hospital of traditional Chinese Medicine, NO. 36 Lihai Road, Liwan District, Guangzhou 510120, Guangdong Province, China. 13602495696@163.com
Research Domain of This Article
Surgery
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Nov 16, 2022; 10(32): 11942-11948 Published online Nov 16, 2022. doi: 10.12998/wjcc.v10.i32.11942
Primary squamous cell carcinoma with sarcomatoid differentiation of the kidney associated with ureteral stone obstruction: A case report
Xue-Hua Liu, Qian-Ming Zou, Jia-Dong Cao, Zhi-Chao Wang
Xue-Hua Liu, Qian-Ming Zou, Jia-Dong Cao, Zhi-Chao Wang, Department of Urology Surgery, Fangcun Hospital of Guangdong Provincial Hospital of traditional Chinese Medicine, Guangzhou 510120, Guangdong Province, China
Author contributions: Liu XH conducted the literature search, collected data, interpreted the data, and prepared the manuscript; Zou QM collected data, interpreted the data, edited the manuscript, and critically revised the draft; Cao JD interpreted the data and critically revised the draft; Wang ZC designed the study, interpreted the data, edited the manuscript, and critically revised the draft; all authors have read and approved the final version to be published.
Informed consent statement: The patient provided written informed consent for publication of this report and accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Chao Wang, MD, Attending Doctor, Department of Urology Surgery, Fangcun Hospital of Guangdong Provincial Hospital of traditional Chinese Medicine, NO. 36 Lihai Road, Liwan District, Guangzhou 510120, Guangdong Province, China. 13602495696@163.com
Received: July 3, 2022 Peer-review started: July 3, 2022 First decision: August 21, 2022 Revised: September 2, 2022 Accepted: October 11, 2022 Article in press: October 11, 2022 Published online: November 16, 2022 Processing time: 128 Days and 2.5 Hours
Abstract
BACKGROUND
Primary squamous cell carcinoma (SCC) with sarcomatoid differentiation of the kidney was rarely reported. This disease is usually related to renal stones, and due to a lack of symptoms and radiological features, patients usually attend the hospital with late stage disease.
CASE SUMMARY
A 54-years-old female presented with left flank pain and an abdominal mass for 6 mo. Imaging studies revealed that the left kidney was enlarged and massive hydronephrosis was present. A stone was seen in the ureteropelvic junction. The patient subsequently underwent left radical nephrectomy, and histopathological examination of the mass revealed a poorly differentiated renal SCC with sarcomatoid differentiation. After primary surgery, the patient received four cycles of tirelizumab. Four months later, the patient developed adrenal, lymph, and uterine appendage metastases.
CONCLUSION
SCC of the kidney has a poor prognosis, and should be considered in patients with a renal mass, long-standing urinary calculi and massive hydronephrosis.
Core Tip: Squamous cell carcinoma (SCC) with sarcomatoid differentiation is extremely rare and has a poor prognosis. The presence of SCC should be considered when a renal mass is found in a patient with long-term stones and hydronephrosis. Early surgical treatment may be beneficial.
