Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 26, 2022; 10(30): 11146-11154
Published online Oct 26, 2022. doi: 10.12998/wjcc.v10.i30.11146
Synchronous gastric cancer complicated with chronic myeloid leukemia (multiple primary cancers): A case report
Yong-Xun Zhao, Ze Yang, Li-Bin Ma, Jia-Yao Dang, Hui-Ying Wang
Yong-Xun Zhao, Ze Yang, Li-Bin Ma, The Seventh Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China
Jia-Yao Dang, Hui-Ying Wang, The First Clinical Medical School, The First Clinical Medical School of Lanzhou University, Lanzhou 730000, Gansu Province, China
Author contributions: Zhao YX, Yang Z, and Dang JY performed the experiments and image acquisition; Zhao YX, Yang Z, Ma LB, and Wang HY designed the study and wrote the manuscript; Zhao YX, Yang Z, and Ma LB edited the manuscript.
Supported by Natural Science Foundation of Gansu Province, China, No. 17JR5RA272; Research Fund project of The First Hospital of Lanzhou University, No. ldyyyn2021-120, No. ldyyyn2020-98, and No. ldyyyn2021-30.
Informed consent statement: This study was approved by the Ethics Committee of the First Hospital of Lanzhou University. The patient was not required to provide informed consent, as the analysis used anonymized clinical data, obtained after obtaining written consent to treatment.
Conflict-of-interest statement: All authors have no conflicts of interest to declare.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016) and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ze Yang, MS, Surgeon, The Seventh Department of General Surgery, The First Hospital of Lanzhou University, No. 1 Donggang West Road, Lanzhou 730000, Gansu Province, China. doccrazy11@13.com
Received: July 1, 2022
Peer-review started: July 1, 2022
First decision: August 1, 2022
Revised: August 9, 2022
Accepted: September 12, 2022
Article in press: September 12, 2022
Published online: October 26, 2022
Processing time: 112 Days and 0.6 Hours
Abstract
BACKGROUND

With the advancement of medical technology and improvement in living standards, the incidence of multiple primary cancers has gradually increased. In particular, tumors of the digestive system account for a large proportion of multiple primary cancers. The diagnosis and treatment of chronic myeloid leukemia, particularly with synchronous gastric cancer, at the first consultation is relatively rare.

CASE SUMMARY

Herein, we present the case of a middle-aged man who was referred to the Department of Hematology owing to an elevated white blood cell count. After the examination, he was diagnosed with chronic myeloid leukemia and was administered imatinib. Three months after the initial diagnosis, he visited our hospital again for abdominal pain, and further examination revealed gastric malignancy. After discussion with a multidisciplinary team, S-1 (Tegafur, Gimeracil, and Oteracil Potassium Capsules) combined with oxaliplatin—SOX regimen—was initiated. Later, the patient’s condition rapidly progressed. He developed colonic obstruction and underwent an ostomy; however, he died less than 6 months after the initial diagnosis.

CONCLUSION

Multiple primary cancers are influenced by environmental and genetic factors; a standardized multidisciplinary discussion plays a key role in treatment.

Keywords: Multiple primary cancers; Gastric cancer; Leukemia; Leukemia inhibitory factor; Case report

Core Tip: Digestive system tumors consist of a large proportion of multiple primary cancers. In this study, we present the case of a patient with gastric cancer and concomitant chronic myeloid leukemia. To better diagnose and treat such patients, we reviewed the literature available on leukemia complicated by gastric cancer-related multiple primary cancers and analyzed its disease mechanisms, clinical symptoms, and treatment alternatives. This study will be a useful reference for the diagnosis and treatment of patients with such conditions.