Yang HJ, Huang X. Synchronous renal pelvis carcinoma associated with small lymphocytic lymphoma: A case report. World J Clin Cases 2022; 10(29): 10663-10669 [PMID: 36312488 DOI: 10.12998/wjcc.v10.i29.10663]
Corresponding Author of This Article
Xiao Huang, MD, PhD, Chief Doctor, Professor, Surgeon, Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. xiaohuang69@zju.edu.cn
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Oct 16, 2022; 10(29): 10663-10669 Published online Oct 16, 2022. doi: 10.12998/wjcc.v10.i29.10663
Synchronous renal pelvis carcinoma associated with small lymphocytic lymphoma: A case report
Han-Jin Yang, Xiao Huang
Han-Jin Yang, Department of Pathology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Xiao Huang, Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Author contributions: Yang HJ contributed to data collection, histopathology, and manuscript drafting; Huang X contributed to patient treatment and follow-up, and manuscript writing and revision.
Informed consent statement: Written consent was obtained from the patient for the publication of this case report.
Conflict-of-interest statement: All authors declare that they have no competing interests with any individual or organization.
CARE Checklist (2016) statement: The CARE Checklist (2016) document has finished and uploaded according to the request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao Huang, MD, PhD, Chief Doctor, Professor, Surgeon, Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. xiaohuang69@zju.edu.cn
Received: April 27, 2022 Peer-review started: April 27, 2022 First decision: July 29, 2022 Revised: August 12, 2022 Accepted: September 6, 2022 Article in press: September 6, 2022 Published online: October 16, 2022 Processing time: 155 Days and 2.6 Hours
Abstract
BACKGROUND
Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is often associated with an increased risk of developing subsequent neoplasms of epithelial and mesenchymal origin. Coincidence of CLL/SLL and urothelial carcinoma (UC) is very rare. Herein, we report a case of synchronous renal pelvis carcinoma with SLL.
CASE SUMMARY
A 78-year-old man presented with the complaint of terminal painless gross hematuria for the past 2 mo. On physical examination, enlarged lymph nodes were palpable in the cervical and axillary regions. The patient’s peripheral blood film was normal. He had a significant smoking history for the past 50 years. Cystoscopy revealed bleeding in the left upper urinary tract. Abdominal computed tomography imaging demonstrated a left renal pelvis tumor. The patient underwent laparoscopic radical nephroureterectomy. Histopathology revealed left renal pelvis high-grade invasive papillary UC and SLL involving the kidney and bone marrow. Renal pelvis lymphatic tissue and lymphocytes were positive for CD5, CD20, and CD23. In addition, the following results were obtained: CD3 (-), Ki-67 (30%+), Bcl-2 (+), Bcl-6 (+), CD10 (-), and CD79a (+). Moreover, no UC metastasis was observed in the lymph nodes.
CONCLUSION
This is the first case of coincident CLL/SLL and upper tract UC in the literature. Cancer patients with lymphadenopathies should always be investigated to rule out the possibility of synchronous or metachronous malignancy.
Core Tip: Coincidence of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and urothelial carcinoma (UC) is very rare. We report a case of synchronous renal pelvis carcinoma with SLL. This is the first case of coincident CLL/SLL and upper tract UC in the literature. Cancer patients should always be investigated to rule out the possibility of a synchronous or metachronous malignancy.
