Case Report
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World J Clin Cases. Oct 16, 2022; 10(29): 10543-10549
Published online Oct 16, 2022. doi: 10.12998/wjcc.v10.i29.10543
Klippel-Trenaunay-Weber syndrome with ischemic stroke: A case report
Geunsu Lee, Taegi Choi
Geunsu Lee, Taegi Choi, Department of Rehabilitation Medicine, Kwangju Christian Hospital, Gwangju 61661, South Korea
Author contributions: Lee G and Choi T contributed equally to this work; Lee G and Choi T designed the research; Lee G and Choi T performed the research; Lee G and Choi T wrote the paper
Informed consent statement: Informed written consent was obtained from the patient for the publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
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Corresponding author: Taegi Choi, MD, Doctor, Department of Rehabilitation, Kwangju Christian Hospital, 37, Yangnim-ro, Nam-gu, Korea, Gwangju 61661, South Korea. chlxorl987@gmail.com
Received: August 24, 2021
Peer-review started: August 24, 2021
First decision: September 29, 2021
Revised: December 13, 2021
Accepted: September 1, 2022
Article in press: September 1, 2022
Published online: October 16, 2022
Processing time: 400 Days and 23.9 Hours
Abstract
BACKGROUND

Klippel-Trenaunay-Weber syndrome (KTWS) is a very rare syndrome that involves three conditions: Cutaneous hemangiomas, varicosities, and soft-tissue hypertrophy of the affected limb. There are few cases of ischemic infarction with KTWS. Here, we describe a case of KTWS with ischemic stroke.

CASE SUMMARY

A 43-year-old man was diagnosed with KTWS with ischemic stroke. His chief complaints were worsening weakness and spasticity in the right leg. These symptoms had been present for 1 year, but the patient did not receive comprehensive rehabilitation until he underwent a 3-week integrated inpatient rehabilitation program at our center. After the program, his muscle strength, walking ability, and exercise endurance improved. Although relatively rare, clinicians should consider the possibility of a thromboembolic event in KTWS patients. Integrated rehabilitation can help such patients to recover function.

CONCLUSION

In conclusion, although rare, patients with KTWS may experience central nervous system vascular malformations and accompanying stroke. It is necessary to investigate whether such patients have any neurological or comorbid abnormalities. Even in the subacute or chronic period after neurological insult, integrated rehabilitation programs can lead to structural and functional enhancement.

Keywords: Klippel-Trenaunay-Weber syndrome; Ischemic stroke; Peripheral arterial disease; Exercise program; Case report

Core Tip: Klippel-Trenaunay-Weber syndrome (KTWS) is a very rare syndrome that involves three conditions: Cutaneous hemangiomas, varicosities, and soft-tissue hypertrophy of the affected limb. There are few cases of ischemic infarction with KTWS. Here, we describe a 43-year-old man who was diagnosed with KTWS with ischemic stroke. His chief complaints were worsening weakness and spasticity in the right leg. These symptoms had been present for 1 year, but the patient did not receive comprehensive rehabilitation until he underwent a 3-wk integrated inpatient rehabilitation program at our center. After the program, his muscle strength, walking ability, and exercise endurance improved. Although relatively rare, clinicians should consider the possibility of a thromboembolic event in KTWS patients. Integrated rehabilitation can help such patients to recover function.