Shu XY, Dai Z, Zhang S, Yang HX, Bi H. Endometrial squamous cell carcinoma originating from the cervix: A case report. World J Clin Cases 2022; 10(24): 8782-8787 [PMID: 36157822 DOI: 10.12998/wjcc.v10.i24.8782]
Corresponding Author of This Article
Hui Bi, MD, Chief Doctor, Department of Gynecology and Obstetrics, Peking University First Hospital, Xishiku Street, Beijing 100034, China. bihuipku@163.com
Research Domain of This Article
Obstetrics & Gynecology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Aug 26, 2022; 10(24): 8782-8787 Published online Aug 26, 2022. doi: 10.12998/wjcc.v10.i24.8782
Endometrial squamous cell carcinoma originating from the cervix: A case report
Xin-Yu Shu, Zhang Dai, Shuang Zhang, Hui-Xia Yang, Hui Bi
Xin-Yu Shu, Zhang Dai, Hui-Xia Yang, Hui Bi, Department of Gynecology and Obstetrics, Peking University First Hospital, Beijing 100034, China
Shuang Zhang, Department of Pathology, Peking University First Hospital, Beijing 100034, China
Author contributions: Shu XY wrote the manuscript; Zhang D performed the surgery and was involved in the patient's direct care; Zhang S provided all the pathological images and revised the pathologial part of the manuscript; Yang HX revised the manuscript; Bi H revised the manuscript critically for important intellectual content, and all authors have read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for the publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hui Bi, MD, Chief Doctor, Department of Gynecology and Obstetrics, Peking University First Hospital, Xishiku Street, Beijing 100034, China. bihuipku@163.com
Received: April 14, 2022 Peer-review started: April 14, 2022 First decision: May 31, 2022 Revised: June 12, 2022 Accepted: July 20, 2022 Article in press: July 20, 2022 Published online: August 26, 2022 Processing time: 123 Days and 19.8 Hours
Abstract
BACKGROUND
Cervical squamous cell carcinoma (SCC) is the most common type of cervical carcinoma and is generally derived from a precancerous stage called cervical high-grade squamous intraepithelial lesion (HSIL). Usually, the cancer metastasizes through lymphatic or hematogenous dissemination, but rarely spreads upward into the uterus. Here, we report a case of cervical HSIL extending into the endometrium and finally progressing to SCC in the uterine cavity.
CASE SUMMARY
A 57-year-old postmenopausal woman visited our department and requested a routine cervical check-up. Four years ago, she had undergone a cervical loop electrosurgical excision procedure because of HSIL found during the gynecological examination, and she had not been checked again since. This time, a relapse of the cervical HSIL was diagnosed along with uterine pyometra and endometrial polyps. After 2 wk of antibiotic treatment, a laparoscopic hysterectomy was performed, and the final pathological examination revealed that the cervical HSIL had spread directly upward into the uterine cavity, gradually developing into cervical SCC in the endometrium.
CONCLUSION
Cervical HSIL/SCC can directly spread upward into the uterus with the most common symptoms of pyometra and cervical stenosis. More attention should be given to the early detection and prevention of this disease.
Core Tip: Under unique circumstances, cervical cancer or precancerous lesions can spread directly upward into the uterine cavity, forming endometrial squamous cell carcinoma, which may alter staging and affect prognosis. Emphasis should be placed on prevention as well as early diagnosis, and although a gynecological ultrasound and an endometrial biopsy may help, their impact is still limited. It is imperative to explore the best clinical strategies for treating this disease.
