Published online Aug 6, 2022. doi: 10.12998/wjcc.v10.i22.8018
Peer-review started: February 16, 2022
First decision: June 15, 2022
Revised: June 22, 2022
Accepted: June 30, 2022
Article in press: June 30, 2022
Published online: August 6, 2022
Processing time: 155 Days and 15.8 Hours
The clinical manifestations of drug eruption are complex and diverse, which can lead to missed diagnosis or misdiagnosis. The clinical manifestations of drug eruption caused by compound honeysuckle have not been reported.
A 20-year-old man was admitted to our department of dermatology due to erythema and papules on the chest and abdomen with pruritus for 3 d. The next day after taking compound honeysuckle granules, the patient suddenly developed a rash and intense itching on his chest and abdomen. Physical examination revealed diffuse red needle-cap size macules and papules with well-defined borders on the chest and abdomen, and discoloration after finger pressure. No abnormality was observed in other areas of the skin. Back skin scratch was positive. White blood cells, eosinophil count and eosinophil ratio were higher than normal. Histopathological examination of the skin lesions on the left abdomen revealed intercellular edema, blurred focal basal cell layers, and focal lymphocyte infiltration in the superficial dermis and perivascular areas. Immunohistochemistry showed CD3+, CD4+ and CD8+ T lymphocytes. The diagnosis was drug eruption with special manifestations induced by compound honeysuckle. The skin lesions completely subsided without pruritus after 2 wk of antihistamine and hormone therapy. Follow-up for > 1 mo showed no recurrence.
Chinese patent medicine compound honeysuckle granules can induce allergic reaction and rare skin damage.
Core Tip: Drug eruption is a common disease in dermatology. The severity of the disease varies, and it can endanger life. The clinical manifestations of drug eruption are complex and varied, and it can imitate any skin disease. Here, we report a case of drug eruption caused by oral administration of Chinese patent medicine compound honeysuckle granules. The clinical manifestations of drug eruption are unique, and the drug eruption is distributed along the Blaschko line on both sides of the chest and abdomen, which is rare clinically.