Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 6, 2022; 10(22): 8018-8024
Published online Aug 6, 2022. doi: 10.12998/wjcc.v10.i22.8018
Compound-honeysuckle-induced drug eruption with special manifestations: A case report
Li-Feng Zhou, Rong Lu
Li-Feng Zhou, Department of Dermatology, The 942nd Hospital of the People's Liberation Army Joint Logistic Support Force, Yinchuan 750004, Ningxia Hui Autonomous Region, China
Rong Lu, Department of Pathology, The 942nd Hospital of the People's Liberation Army Joint Logistic Support Force, Yinchuan 750004, Ningxia Hui Autonomous Region, China
Author contributions: Zhou LF and Lu R contributed equally to this work; Zhou LF contributed to the manuscript by tracing the history, reviewing the literature, collecting and analyzing clinical data and figures, and writing the manuscript; Lu R contributed to conception of the article, literature retrieval, photography and editing, and manuscript revision and polishing.
Informed consent statement: Informed consent was obtained from the patient.
Conflict-of-interest statement: All authors declare no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rong Lu, MMed, Director, Department of Pathology, the 942nd Hospital of the People's Liberation Army Joint Logistic Support Force, No. 893 Shengli South Street, Xingqing District, Yinchuan 750004, Ningxia Hui Autonomous Region, China. lrzlf@sohu.com
Received: February 16, 2022
Peer-review started: February 16, 2022
First decision: June 15, 2022
Revised: June 22, 2022
Accepted: June 30, 2022
Article in press: June 30, 2022
Published online: August 6, 2022
Processing time: 155 Days and 15.8 Hours
Abstract
BACKGROUND

The clinical manifestations of drug eruption are complex and diverse, which can lead to missed diagnosis or misdiagnosis. The clinical manifestations of drug eruption caused by compound honeysuckle have not been reported.

CASE SUMMARY

A 20-year-old man was admitted to our department of dermatology due to erythema and papules on the chest and abdomen with pruritus for 3 d. The next day after taking compound honeysuckle granules, the patient suddenly developed a rash and intense itching on his chest and abdomen. Physical examination revealed diffuse red needle-cap size macules and papules with well-defined borders on the chest and abdomen, and discoloration after finger pressure. No abnormality was observed in other areas of the skin. Back skin scratch was positive. White blood cells, eosinophil count and eosinophil ratio were higher than normal. Histopathological examination of the skin lesions on the left abdomen revealed intercellular edema, blurred focal basal cell layers, and focal lymphocyte infiltration in the superficial dermis and perivascular areas. Immunohistochemistry showed CD3+, CD4+ and CD8+ T lymphocytes. The diagnosis was drug eruption with special manifestations induced by compound honeysuckle. The skin lesions completely subsided without pruritus after 2 wk of antihistamine and hormone therapy. Follow-up for > 1 mo showed no recurrence.

CONCLUSION

Chinese patent medicine compound honeysuckle granules can induce allergic reaction and rare skin damage.

Keywords: Drug eruption; Drug dermatitis; Blaschko line; Compound honeysuckle; Allergic reaction; Case report

Core Tip: Drug eruption is a common disease in dermatology. The severity of the disease varies, and it can endanger life. The clinical manifestations of drug eruption are complex and varied, and it can imitate any skin disease. Here, we report a case of drug eruption caused by oral administration of Chinese patent medicine compound honeysuckle granules. The clinical manifestations of drug eruption are unique, and the drug eruption is distributed along the Blaschko line on both sides of the chest and abdomen, which is rare clinically.