Published online Aug 6, 2022. doi: 10.12998/wjcc.v10.i22.7931
Peer-review started: November 3, 2021
First decision: November 19, 2021
Revised: December 15, 2021
Accepted: June 27, 2022
Article in press: June 27, 2022
Published online: August 6, 2022
Processing time: 260 Days and 16.3 Hours
Primary hypertension is a common clinical disease. Pheochromocytoma and paraganglioma is a rare cause of secondary hypertension. The diagnosis of the latter is still difficult, and the relationship between the two is not clear. The successful diagnosis of this case confirmed that standardized etiological investigation of secondary hypertension is necessary, contributes to the accurate diagnosis of rare diseases, and is conducive to the formulation or optimization of treatment plans. It shows an example of the coexistence of primary hypertension and secondary hypertension.
The patient was a 54-year-old male and was hospitalized with high blood pressure for 4 years. The patient’s blood pressure was measured at 150/100 mmHg during physical examination 4 years ago and had no paroxysmal or persistent elevated blood pressure, no typical triad of headache, palpitation, and sweating, without postural hypotension. After taking nifedipine sustained release tablets intermittently, the blood pressure did not meet the standard. Physical examination revealed blood pressure of 180/120 mmHg. There was no abnor
Subclinical paraganglioma and primary hypertension can coexist. The holistic thinking in clinical practice is helpful to the early diagnosis of rare diseases.
Core Tip: Pheochromocytoma and paraganglioma (PPGL) is a rare cause of secondary hypertension, and early and accurate diagnosis is still facing challenges. A case of subclinical paraganglioma (PGL) complicated with essential hypertension was analyzed retrospectively. A typical and subclinical pheochromocytoma and PGL should be paid more attention due to the lack of clinical features. At the same time, standardized etiological investigation of secondary hypertension is also an indispensable part of an accurate diagnosis. Clinical practice has proven that subclinical PGL and essential hypertension are two independent diseases that can coexist. After reviewing the literature, it is considered that genetic susceptibility is the same pathogenic factor.